ArticleCell reports2024
Retrosplenial inputs drive visual representations in the medial entorhinal cortex.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- The entorhinal spatial map integrates visual identity information of landmarks.Nature communications · 2026Article
- Theta Activity Supports Landmark-Based Correction of Naturalistic Human Path Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- Brief sleep disruption following hippocampus-dependent learning downscales interneuron synapses within lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Higher-order thalamic input to cortex selectively conveys state information.Cell reports · 2025Article
- NMDA receptor antagonist induced c-Fos expression in the medial entorhinal cortex during postnatal development.Frontiers in neural circuits · 2025Article
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2 authors.
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Abstract
The importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the medial entorhinal cortex (MEC), which receives direct projections from neocortical visual areas, including the retrosplenial cortex (RSC). Here, we perform high-density recordings of MEC neurons in awake, head-fixed mice presented with simple visual stimuli and assess the dynamics of sensory-evoked activity. We find that a large fraction of neurons exhibit robust responses to visual input. Visually responsive cells are located primarily in layer 3 of the dorsal MEC and can be separated into subgroups based on functional and molecular properties. Furthermore, optogenetic suppression of RSC afferents within the MEC strongly reduces visual responses. Overall, our results demonstrate that the MEC can encode simple visual cues in the environment that may contribute to neural representations of location necessary for accurate navigation.
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