Evidence map›Paper›PMID 38985464›Full record

ArticleJournal of the American Chemical Society2024

Tool to Resolve Distortions in Elemental and Isotopic Imaging.

Chixiang Lu, Gu Chen, Wenxin Song, Kai Chen, Charmaine Hee, Mehran Nikan, Paul Guagliardo, C Frank Bennett, Punit Seth, Killugudi Swaminathan Iyer and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chixiang LuDepartment of Chemistry, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.
Gu ChenDepartment of Chemistry, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.
Wenxin SongDepartments of Medicine, University of California, Los Angeles, California 90095, United States.
Kai ChenSchool of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
Charmaine HeeSchool of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
Mehran NikanIonis Pharmaceuticals, Inc., Carlsbad, California 92010, United States.
Paul GuagliardoCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
C Frank BennettIonis Pharmaceuticals, Inc., Carlsbad, California 92010, United States.
Punit SethIonis Pharmaceuticals, Inc., Carlsbad, California 92010, United States.ORCID 0000-0002-1783-7806
Killugudi Swaminathan IyerSchool of Molecular Sciences, University of Western Australia, Perth 6009, Australia.ORCID 0000-0001-9329-4930
Stephen G YoungDepartments of Medicine, University of California, Los Angeles, California 90095, United States.
Xiaojuan QiElectrical and Electronic Engineering, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.
Haibo JiangDepartment of Chemistry, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.ORCID 0000-0002-2384-4826

Funding

Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2019 to 2023
$11.7M
Investigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1M
Regulation of Intravascular Triglyceride HydrolysisR35HL176438 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Stephen G. Young · 2025 to 2026
$2.2M
NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R35 HL139725NHLBI NIH HHS R35 HL176438
6 · The paper itself

Abstract

Nanoscale secondary ion mass spectrometry (NanoSIMS) makes it possible to visualize elements and isotopes in a wide range of samples at a high resolution. However, the fidelity and quality of NanoSIMS images often suffer from distortions because of a requirement to acquire and integrate multiple image frames. We developed an optical flow-based algorithm tool, NanoSIMS Stabilizer, for all-channel postacquisition registration of images. The NanoSIMS Stabilizer effectively deals with the distortions and artifacts, resulting in a high-resolution visualization of isotope and element distribution. It is open source with an easy-to-use ImageJ plugin and is accompanied by a Python version with GPU acceleration.

Identifiers

PMID38985464
PMCPMC12826797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.