Evidence map›Paper›PMID 38985449›Full record

ArticleAging2024

Co-analysis of methylation platforms for signatures of biological aging in the domestic dog reveals previously unexplored confounding factors.

Aitor Serres Armero, Reuben M Buckley, Lajoyce Mboning, Gabriella J Spatola, Steve Horvath, Matteo Pellegrini, Elaine A Ostrander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aitor Serres ArmeroCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Reuben M BuckleyCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Lajoyce MboningDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Gabriella J SpatolaCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of Los Angeles, Los Angeles, CA 90095, USA.
Elaine A OstranderCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Comparative Mammalian GenomicsZIAHG200377 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2012 to 2025
$24.8M
6 · The paper itself

Abstract

Chronological age reveals the number of years an individual has lived since birth. By contrast, biological age varies between individuals of the same chronological age at a rate reflective of physiological decline. Differing rates of physiological decline are related to longevity and result from genetics, environment, behavior, and disease. The creation of methylation biological age predictors is a long-standing challenge in aging research due to the lack of individual

Indexed as

AgingDNA MethylationLongevityAnimalsDogsEpigenesis, Geneticbiological agedoglifespanmethylationpenalized regression

Identifiers

PMID38985449
PMCPMC11272130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.