Evidence map›Paper›PMID 38985417›Full record

ArticleIrish journal of medical science2024

Zinc finger 259 gene polymorphisms in Egyptian patients with metabolic syndrome and its association with dyslipidemia.

Doha El-Sayed Ellakwa, Khaleda Sayed Amr, Moushira Erfan Zaki, Miral Refeat, Hala Mohamed Banksle

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Article in Irish journal of medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

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10citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. From metabolic dysregulation to malignancy: the presence ofJournal of gastrointestinal oncology · 2026
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Doha El-Sayed EllakwaDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. profdoha@gmail.com.ORCID http://orcid.org/0000-0003-4824-3485
Khaleda Sayed AmrDepartment of Medical Molecular Genetics, National Research Centre (NRC), Dokki, Giza, Egypt.
Moushira Erfan ZakiDepartment of Biological Anthropology, Medical Researches and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
Miral RefeatDepartment of Medical Molecular Genetics, Human Genetics and Genome Research Institute, Cairo, Egypt.
Hala Mohamed BanksleDepartment of Biochemistry, Faculty of Pharmacy, Aleppo University, Aleppo, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundZinc finger protein 1 (ZPR1), encoded by the ZNF259 gene, plays crucial roles in transcriptional regulation and cell cycle progression. Despite its known functions, its specific involvement in Metabolic Syndrome (MetS) remains debated. Genome-wide association studies have identified several genes, including ZNF259, implicated in lipid metabolism and associated with MetS. Single nucleotide polymorphisms (SNPs) in ZNF259 have been linked to altered lipid metabolism during the development of MetS. This study aims to investigate the association between MetS in Egyptian patients and three specific ZNF259 SNPs: rs964184, rs2075294, and rs2075290. The objective is to explore how these SNPs correlate with MetS development, other health outcomes, and their interaction with dyslipidemia biomarkers.

methods200 Egyptian participants were enrolled, and divided into two groups: 100 patients diagnosed with dyslipidemia and 100 healthy controls. The study involved comprehensive assessments, including lipid profile analysis, anthropometric measurements, and genotyping of rs964184, rs2075290, and rs2075294 in the ZNF259 gene using Real-Time Polymerase Chain Reaction (PCR).

resultsThe findings indicate that rs964184 SNP correlates significantly with elevated plasma triacylglycerol (TG) levels, while rs2075290 and rs2075294 are associated with higher total serum cholesterol (TC) and TG levels. Among these SNPs, rs2075294 showed the highest predictive value (area under the curve of 0.748), followed by rs2075290 (0.738), and rs964184 (0.583), suggesting rs2075294 as the most influential SNP in MetS prediction.

conclusionThis study underscores the predictive role of ZNF259 SNPs in MetS risk among Egyptians. Future research should further explore the implications of ZNF259 in MetS pathogenesis and its potential as a biomarker for personalized health interventions.

Indexed as

DyslipidemiasMembrane Transport ProteinsMetabolic SyndromePolymorphism, Single NucleotideAdultCase-Control StudiesEgyptFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedTriglyceridesMembrane Transport ProteinsTriglyceridesZPR1 protein, humanDyslipidemiaGene polymorphismLipid pathwayMetabolic syndromeZinc finger 259 genes

Identifiers

PMID38985417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.