Evidence map›Paper›PMID 38985374›Full record

ArticleStem cell reviews and reports2024

Autotaxin Inhibition Reduces Post-Ischemic Myocardial Inflammation via Epigenetic Gene Modifications.

Landys Z Guo, Himi Tripathi, Erhe Gao, Wadea M Tarhuni, Ahmed Abdel-Latif

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In one paragraph

Article in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Landys Z GuoDepartment of Biology, University of Kentucky, Lexington, KY, USA.
Himi TripathiMichigan Medicine, Division of Internal Medicine Cardiology, University of Michigan, and the Ann Arbor VA Healthcare System, Ann Arbor, MI, USA.
Erhe GaoCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Wadea M TarhuniCanadian Cardiac Research Center, Department of Internal Medicine, Division of Cardiology, University of Saskatchewan, Saskatoon, SK, Canada.
Ahmed Abdel-LatifMichigan Medicine, Division of Internal Medicine Cardiology, University of Michigan, and the Ann Arbor VA Healthcare System, Ann Arbor, MI, USA. aalatif@umich.edu.ORCID 0000-0002-8178-7102

Funding

Role of Bioactive Lipids in Stem Cell Mobilization and Homing in Cardiac IschemiaR56HL124266 · NHLBI · UNIVERSITY OF KENTUCKY · PI ABDEL-LATIF, AHMED · 2014 to 2014
$375k
NHLBI Division of Intramural Research HL124266Veterans Medical Research Foundation 1 I01 CX002684-01
6 · The paper itself

Abstract

Myocardial infarction (MI) triggers a complex inflammatory response that is essential for cardiac repair but can also lead to adverse outcomes if left uncontrolled. Recent studies have highlighted the importance of epigenetic modifications in regulating post-MI inflammation. This study investigated the role of the autotaxin (ATX)/lysophosphatidic acid (LPA) signaling axis in modulating myocardial inflammation through epigenetic pathways in a mouse model of MI. C57BL/6 J mice underwent left anterior descending coronary artery ligation to induce MI and were treated with the ATX inhibitor, PF-8380, or vehicle. Cardiac tissue from the border zone was collected at 6 h, 1, 3, and 7 days post-MI for epigenetic gene profiling using RT

Indexed as

Epigenesis, GeneticMice, Inbred C57BLMyocardial InfarctionPhosphoric Diester HydrolasesAnimalsDisease Models, AnimalInflammationLysophospholipase DLysophospholipidsMaleMiceMyocardial IschemiaMyocardiumSignal Transductionlysophosphatidic acidLysophospholipase DLysophospholipidsPhosphoric Diester HydrolasesAutotaxin inhibitorEpigeneticsGene expressionMyocardial infarctionMyocardial inflammation

Identifiers

PMID38985374

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.