Evidence map›Paper›PMID 38985343›Full record

ArticleWorld journal of urology2024

Diagnostic performance of photodynamic diagnosis with oral 5-aminolevulinic acid for upper tract- and bladder urothelial carcinoma: a single-centre, retrospective analysis.

Takeshi Sano, Takashi Yoshida, Takahiro Nakamoto, Chisato Ohe, Hisanori Taniguchi, Masaaki Yanishi, Hidefumi Kinoshita

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Takeshi SanoDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan. sanotake@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-5854-6258
Takashi YoshidaDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan.
Takahiro NakamotoDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan.
Chisato OheDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan.
Hisanori TaniguchiDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan.
Masaaki YanishiDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan.
Hidefumi KinoshitaDepartment of Urology and Andrology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata- shi, 573-1010, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the diagnostic performance of photodynamic diagnosis (PDD) enhanced with oral 5-aminolaevulinic acid between the suspected upper tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) cases.

methodsThis retrospective study included 18 patients with suspected UTUC who underwent ureteroscopy (URS) with oral 5-ALA in the PDD-URS cohort between June 2018 and January 2019; and 110 patients with suspected BUC who underwent transurethral resection of bladder tumour (TURBT) in the PDD-TURBT cohort between January 2019 and March 2023. Sixty-three and 708 biopsy samples were collected during diagnostic URS and TURBT, respectively. The diagnostic accuracy of white light (WL) and PDD in the two cohorts was evaluated, and false PDD-positive samples were pathologically re-evaluated.

resultsThe area under the receiver operating characteristic curve (AUC) of PDD was significantly superior to that of WL in both cohorts. The per biopsy sensitivity, specificity, and positive and negative predictive values of PDD in patients in the PDD-URS and PDD-TURBT cohorts were 91.2 vs. 71.4, 75.9 vs. 75.3, 81.6 vs. 66.3, and 88.0 vs. 79.4%, respectively. The PDD-URS cohort exhibited a higher AUC than did the PDD-TURBT cohort (0.84 vs. 0.73). Seven of four false PDD-positive samples (57.1%) in the PDD-URS cohort showed potential precancerous findings compared with eight of 101 (7.9%) in the PDD-TURBT cohort.

conclusionThe diagnostic performance of PDD in the PDD-URS cohort was at least equivalent to that in the PDD-TURBT cohort.

Indexed as

Aminolevulinic AcidCarcinoma, Transitional CellPhotosensitizing AgentsUrinary Bladder NeoplasmsAdministration, OralAgedAged, 80 and overFemaleHumansKidney NeoplasmsMaleMiddle AgedRetrospective StudiesUreteral NeoplasmsUreteroscopyAminolevulinic AcidPhotosensitizing Agents5-aminolevulinic acid hydrochlorideBladder cancerPhotodynamic diagnosisUpper tract urothelial cancerUrothelial carcinoma

Identifiers

PMID38985343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.