SynthesisBlood advances2024
The clinical picture of Castleman disease: a systematic review and meta-analysis.
Synthesis in Blood advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The bleeding puzzle: unmasking a hidden culprit.Internal and emergency medicine · 2026Article
- Diagnostic challenge of human herpesvirus 8-associated multicentric Castleman disease in a patient living with HIV disease.BMJ case reports · 2026Article
- HIV-negative KSHV/HHV8-associated multicentric Castleman disease with concurrent Kaposi sarcoma and POEMS-like manifestations.Journal of hematopathology · 2026Article
- Effective Use of Subcutaneous Tocilizumab in a Case of Castleman Disease Progressing From Unicentric to Multicentric Form.Journal of paediatrics and child health · 2026Article
- Deciphering the full spectrum of Castleman diseases based on a cohort of 700 patients in a western country.British journal of haematology · 2026Article
- From Unicentric Castleman Disease to Lymphoma: A Rare Case Highlighting a Diagnostic and Therapeutic Challenge.Cureus · 2026Article
- Castleman disease arising from the pleura: a case report and literature review.Journal of cancer research and clinical oncology · 2026Review
- Idiopathic Multicentric Castleman's Disease Diagnosed by Pulmonary Histopathology: A Case Report.Respirology case reports · 2026Article
- Review
- Snapshot Look at Castleman Disease.Journal of cellular and molecular medicine · 2026Review
- Unicentric Castleman disease with paraneoplastic pemphigus and follicular dendritic cell sarcoma: A case report.Oncology letters · 2026Article
- Unicentric Castleman disease of plasma cell type in the adrenal region: a case report and literature review.Frontiers in oncology · 2026Article
- Unilateral Renal Castleman Disease Presenting with Acute Abdominal Pain: A Case Report and Literature ReviewCurrent medical imaging · 2026Review
- Unicentric Castleman Disease of the Mesentery Mimicking a Gastrointestinal Stromal Tumor: A Case Report.Cureus · 2026Article
- Castleman disease: clinical features, pathology, and treatment outcomes in 12 cases.Frontiers in oncology · 2026Article
- Article
- A rare case of unicentric Castleman disease in the posterior mediastinum: case report and integrated literature review.Frontiers in oncology · 2026Article
- Article
- [This is how I diagnose Castleman's disease].Zeitschrift fur Rheumatologie · 2025Article
- The sonographic characteristics of unicentric castleman disease - a single-center retrospective study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
abstractCastleman disease (CD) encompasses a spectrum of rare disorders, including unicentric CD (UCD), idiopathic multicentric CD (iMCD), and human herpesvirus 8-associated MCD (HHV8+ MCD). We performed a systematic review of publications reporting ≥5 cases of CD between 1995 and 2021, following preferred reporting items for systematic reviews and meta-analyses guidelines, to describe and compare subtypes. We extracted data on clinical symptoms and laboratory parameters as stated in international consensus diagnostic criteria for iMCD and estimated the frequency of each criterion using meta-analyses. We analyzed 32 studies describing 559 UCD, 1023 iMCD, and 416 HHV8+ MCD cases. Although many symptoms and laboratory abnormalities occurred at similar rates in patients with iMCD and HHV8+ MCD, patients with HHV8+ MCD had significantly higher rates of constitutional symptoms (46.6% vs 98.6%; P = .038) and splenomegaly (48.2% vs 89.2%; P = .031). Renal dysfunction was significantly more common in patients with iMCD than in patients with HHV8+ MCD before adjustment (36.9% vs 17.4%; P = .04; adjusted P = .1). Patients with UCD had lower rates of symptoms and laboratory abnormalities, although these were present in 20% of patients and were particularly pronounced in pediatric UCD. There are many similarities in the symptomatology of iMCD and HHV8+ MCD; many patients experience constitutional symptoms and organ dysfunction. Differences between these subtypes likely reflect differences in pathophysiology and/or comorbidity burdens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.