Evidence map›Paper›PMID 38985258›Full record

ArticleBiotechnology letters2024

Proteome profiling, biochemical and histological analysis of diclofenac-induced liver toxicity in Yersinia enterocolitica and Lactobacillus fermentum fed rat model: a comparative analysis.

Shruti Ahlawat, Hari Mohan, Krishna Kant Sharma

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Biotechnology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shruti AhlawatLaboratory of Enzymology and Recombinant DNA Technology, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Hari MohanCentre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Krishna Kant SharmaLaboratory of Enzymology and Recombinant DNA Technology, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India. kekulsharma@gmail.com.ORCID http://orcid.org/0009-0003-9745-4024

Funding

Department of Science and Technology, Ministry of Science and Technology, India 1196 SR/FST/LS-I/2017/4
6 · The paper itself

Abstract

Diclofenac is a hepatotoxic non-steroidal anti-inflammatory drug (NSAID) that affects liver histology and its protein expression levels. Here, we studied the effect of diclofenac on rat liver when co-administrated with either Yersinia enterocolitica strain 8081 serotype O:8 biovar 1B (D*Y) or Lactobacillus fermentum strain 9338 (D*L). Spectroscopic analysis of stool samples showed biotransformation of diclofenac. When compared with each other, D*Y rats lack peaks at 1709 and 1198 cm

Indexed as

Chemical and Drug Induced Liver InjuryDiclofenacLimosilactobacillus fermentumLiverProteomeYersinia enterocoliticaAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersMaleRatsAnti-Inflammatory Agents, Non-SteroidalBiomarkersDiclofenacProteomeDiclofenacHepatotoxicLactobacillus fermentumNSAIDProteomicsYersinia enterocolitica

Identifiers

PMID38985258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.