ReviewEnvironmental science & technology2024
High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage.
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In one paragraph
Review in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Updated Knowledge on Radon Exposure: Quantification Methods, Health Effects, and Molecular Mechanisms.Environment & health (Washington, D.C.) · 2026Review
- Fast and Scalable Sample Preparation for Integrated Metabolome and Exposome-Wide Association Studies (MWAS/ExWAS).Analytical chemistry · 2026Article
- Column switching liquid chromatography dual mass spectrometry system for simultaneous untargeted metabolomics and targeted exposomics.Nature communications · 2026Article
- Interactive Software for Interpreting and Curating High-Resolution Electron Ionization Mass Spectra.Journal of mass spectrometry : JMS · 2026Article
- Exercise and Sports Metabolomics: Analytical Platforms, Metabolite Annotation, Pathway-Level Interpretation, and Biomarker-Panel Readiness.Metabolites · 2026Review
- ToxBase: A Multidimensional ToxCast Reference Database for High-Throughput Human Exposome Analysis.Environmental science & technology · 2026Article
- IMFrag: A Tool to Recognize In-Source Fragmentation in Ion Mobility-Enabled Data-Independent Acquisition Workflows.Analytical chemistry · 2026Article
- Enhanced Environmental PFAS Characterization Using a Virtual High-Resolution Mass Spectral Library Generated by Transfer Learning-Based Neural Network.Environmental science & technology · 2026Article
- Librarian: An Open-Access Web Application for High-Resolution Mass Spectral Library Assembly.Metabolites · 2026Article
- Assessing the metabolomics "dark matter" by a detectable khipu model.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- The Human Exposome: Integrating the Environment, Human Health, and Society for the Next 60 years.Environmental science & technology · 2026Review
- From Target-Nontarget to Nontarget Screening: A Review on Screening Methods for Organic Pollutants Based on High-Resolution Mass Spectrometry.Environment & health (Washington, D.C.) · 2026Review
- Exposomics Crosses the Rubicon: Let the Building Begin.Environmental science & technology · 2026Article
- Will Chemical Exposomics Be Ready for a Human Exposome Project?Environmental science & technology · 2026Article
- A network-based map of the chemical exposome connects molecular interactions to public health.Nature communications · 2026Article
- Unlocking the Bile Acid Universe: Advanced Workflows and a Multidimensional Library of 280 Unique Species.bioRxiv : the preprint server for biology · 2026Article
- Clean beauty gentrification: The role of historic and contemporary resource allocation practices on hair product safety in Boston, MA.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminaryFrontiers in immunology · 2026Article
- Unlocking the bile acid universe: advanced workflows and a multidimensional library of 280 unique species.Sustainable microbiology · 2026Article
- Artificial intelligence driven exposome and multi omics integration for biomarker discovery in liver cancer: a literature review.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors.
Yunjia LaiDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0002-1081-0897
Jeremy P KoelmelDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, United States.
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States.
Elliott J PriceRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.ORCID 0000-0001-5691-7000
Stefano PapazianDepartment of Environmental Science, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0003-2538-8702
Katherine E ManzDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, United States.
Delia Castilla-FernándezDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, 1010 Vienna, Austria.
John A BowdenCenter for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0003-3135-4015
Vladimir NikiforovNILU, Fram Centre, Tromsø NO-9296, Norway.
Arthur DavidUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S, 1085 Rennes, France.ORCID 0000-0001-8189-1826
Vincent BessonneauUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S, 1085 Rennes, France.
Bashar AmerThermo Fisher Scientific, San Jose, California 95134, United States.
Suresh SeethapathyThermo Fisher Scientific, Somerset, New Jersey 08873, United States.
Xin HuGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States.
Elizabeth Z LinDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, United States.
Akrem JbebliRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
Brooklynn R McNeilBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, New York 10032, United States.
Dinesh BarupalDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.ORCID 0000-0002-9954-8628
Marina CerasaInstitute of Atmospheric Pollution Research, Italian National Research Council, 00015 Monterotondo, Rome, Italy.
Hongyu XieDepartment of Environmental Science, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-2422-0492
Vrinda KaliaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0003-2244-6663
Renu NandakumarBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, New York 10032, United States.
Randolph SinghDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0003-4500-3400
Zhenyu TianDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0002-7491-7028
Peng GaoDepartment of Environmental and Occupational Health, and Department of Civil and Environmental Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0002-4311-584X
Yujia ZhaoInstitute for Risk Assessment Sciences, Utrecht University, Utrecht 3584CM, The Netherlands.ORCID 0000-0002-5275-0036
Jean FromentNILU, PO Box 100, NO-2027 Kjeller, Norway.ORCID 0000-0003-4844-2919
Pawel RostkowskiNILU, PO Box 100, NO-2027 Kjeller, Norway.ORCID 0000-0001-9778-4283
Saurabh DubeyBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, New York 10032, United States.
Kateřina CoufalíkováRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
Hana SeličováRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
Helge HechtRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.ORCID 0000-0001-6744-996X
Sheng LiuDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, United States.
Hanisha H UdhaniBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, New York 10032, United States.
Sophie RestituitoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Kam-Meng Tchou-WongDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Kun LuDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-8125-2394
Jonathan W MartinDepartment of Environmental Science, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0001-6265-4294
Benedikt WarthDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, 1010 Vienna, Austria.ORCID 0000-0002-6104-0706
Krystal J Godri PollittDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, United States.ORCID 0000-0001-7332-2228
Jana KlánováRECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
Oliver FiehnWest Coast Metabolomics Center, University of California-Davis, Davis, California 95616, United States.ORCID 0000-0002-6261-8928
Thomas O MetzBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99354, United States.ORCID 0000-0001-6049-3968
Kurt D PennellSchool of Engineering, Brown University, Providence, Rhode Island 02912, United States.ORCID 0000-0002-5788-6397
Dean P JonesDepartment of Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, United States.
Gary W MillerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0001-8984-1284
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MConduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MTrue Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MPilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6MThe UNC Chapel Hill Superfund Research Program (UNC-SRP)P42ES031007 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Gray · 2020 to 2026
$22.2MGenetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrderR01AG067501 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2024
$11.7MEpidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging ProjectRF1AG066107 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2022
$11.4MU2C Experimental CoreU2CES030163 · NIEHS · EMORY UNIVERSITY · PI MORGAN, EDWARD THOMAS · 2018 to 2021
$3.6MMapping the blood cancer exposome for environmental risk profiles of mature B-cell neoplasmsR01ES032831 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Douglas Ian Walker · 2022 to 2026
$2.3MThe 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigatorsR25GM143298 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IONITA, IULIANA, RE, DIANE BERENGERE · 2021 to 2025
$2.3MAssessment of Early Life PFAS Exposure in Perinatal Biospecimens, Infant Formula, and Breastmilk.K01ES035398 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MANZ, KATHERINE ELIZABETH · 2023 to 2025
$552kNCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR004419NIA NIH HHS R01 AG067501NIA NIH HHS RF1 AG066107NIEHS NIH HHS K01 ES035398NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P42 ES031007NIEHS NIH HHS R01 ES032831NIEHS NIH HHS R21 ES034187NIEHS NIH HHS R21 ES036033NIEHS NIH HHS U2C ES030163NIGMS NIH HHS R25 GM143298NIH HHS R03 OD034497
Abstract
In the modern "omics" era, measurement of the human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics and metabolomics, has emerged as a leading technology to broadly profile chemical exposure agents and related biomolecules for accurate mass measurement, high sensitivity, rapid data acquisition, and increased resolution of chemical space. Non-targeted approaches are increasingly accessible, supporting a shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating chemical exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical and computational infrastructures are needed to expand the analysis coverage through streamlined, scalable, and harmonized workflows and data pipelines that permit longitudinal chemical exposome tracking, retrospective validation, and multi-omics integration for meaningful health-oriented inferences. In this article, we survey the literature on state-of-the-art HRMS-based technologies, review current analytical workflows and informatic pipelines, and provide an up-to-date reference on exposomic approaches for chemists, toxicologists, epidemiologists, care providers, and stakeholders in health sciences and medicine. We propose efforts to benchmark fit-for-purpose platforms for expanding coverage of chemical space, including gas/liquid chromatography-HRMS (GC-HRMS and LC-HRMS), and discuss opportunities, challenges, and strategies to advance the burgeoning field of the exposome.
Indexed as
Mass SpectrometryEnvironmental ExposureExposomeHumansMetabolomicsProteomicschemical spacechromatographyenvironmental exposuresexposomehigh-resolution mass spectrometrymetabolomicsnon-targeted analysistoxicants
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