Evidence map›Paper›PMID 38984584›Full record

ReviewCurrent medicinal chemistry2025

Argyria and Neuropsychiatric Disorders: When not only the Matter is Gray. A Literature Review and a Case Report.

Adriano Bonura, Antonio Siniscalchi, Domenica Crupi, Alessandro Magliozzi, Maria Cristina Bravi, Mattia Internullo, Marilena Mangiardi, Francesca Romana Pezzella, Barbara Schito, Sabrina Anticoli

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adriano BonuraNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio- Medico di Roma, Rome, Italy.
Antonio SiniscalchiDepartment of Neurology and Stroke Unit, Annunziata Hospital of Cosenza, Cosenza, Italy.
Domenica CrupiHead, Neck and Neuroscience Department, San Camillo Forlanini Hospital, Rome, Italy.
Alessandro MagliozziNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio- Medico di Roma, Rome, Italy.
Maria Cristina BraviHead, Neck and Neuroscience Department, San Camillo Forlanini Hospital, Rome, Italy.
Mattia InternulloEmergency Department, San Camillo Forlanini Hospital, Rome, Italy.
Marilena MangiardiHead, Neck and Neuroscience Department, San Camillo Forlanini Hospital, Rome, Italy.
Francesca Romana PezzellaHead, Neck and Neuroscience Department, San Camillo Forlanini Hospital, Rome, Italy.
Barbara SchitoEmergency Department, San Camillo Forlanini Hospital, Rome, Italy.
Sabrina AnticoliHead, Neck and Neuroscience Department, San Camillo Forlanini Hospital, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Argyria is the chronic accumulation of silver in biological tissues such as skin, liver, kidneys, lungs, peripheral nerves, and brain. The presence of an actual pathophysiological and clinical correlate related to silver encephalic and peripheral nerve deposition is still much debated. In this paper, we reviewed and described case reports regarding argyria associated with neuropsychiatric symptoms in order to explain the underlying mechanism of the disease. We conducted a narrative review by searching for case reports that described subjects with chronic silver accumulation and who had associated neurological or psychiatric symptoms. Moreover, we report a case of a 50-year-old man admitted to our hospital with a diagnosis of major depression who presented with worsening psychiatric symptoms after abuse of silver-containing nasal spray. We found 15 cases of patients with argyria and neuropsychiatric manifestations such as epilepsy, neurodegenerative syndromes, multiple sclerosis, peripheral neuropathy, and psychiatric disorders. The knowledge of possible pathogenetic mechanisms and recognition of clinical features of argyria can help clinicians prevent brain deposition and its complications.

Indexed as

ArgyriaMental DisordersHumansMaleMiddle AgedSilverSilveradult patientArgyriabrain.neuropsychiatric disorderssilvertoxicology

Identifiers

PMID38984584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.