Evidence map›Paper›PMID 38984569›Full record

ArticleInfectious disorders drug targets2025

Molecular Characterization of Antimicrobial Resistance and Virulence Genotyping among

Ebrahim Kouhsari, Gholamreza Roshandel, Sara Hosseinzadeh, Sima Besharat, Vahid Khori, Taghi Amiriani

Abstract read
PubMed Publisher
In one paragraph

Article in Infectious disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Challenges and Prospects for Eradication ofPathogens (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ebrahim KouhsariLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Gholamreza RoshandelGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Sara HosseinzadehLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Sima BesharatGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Vahid KhoriIschemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Taghi AmirianiGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.

Funding

Golestan University of Medical Sciences 111190
6 · The paper itself

Abstract

backgroundIran has a relatively high prevalence of

methodsOur study aimed to investigate the underlying genetic mechanisms associated with resistance to metronidazole (frxA, rdxA), clarithromycin (23S rRNA), tetracycline (16S rRNA), and fluoroquinolone (gyrA) in

resultsThe rates of genetic mutations associated with resistance to metronidazole, fluoroquinolone, clarithromycin, and tetracycline were found to be 68%, 32.1%, 28.4%, and 11.1%, respectively. Well-documented multiple antibiotic resistance mutations were detected, such as rdxA and frxA (with missense and frameshift alterations), gyrA (Asp91, Asn87), 23S rRNA (A2142G, A2143G), and 16S rRNA (triple-base-pair substitutions AGA926-928→TTC). The cagA+ and vacA s1/m1 types were the predominant genotypes in our study. With the exception of metronidazole and tetracycline, no significant correlation was observed between the cagA+ and cagL+ genotypes and resistance-associated mutations.

conclusionThe prevalence of antibiotic resistance-associated mutations in

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialDyspepsiaHelicobacter InfectionsHelicobacter pyloriAdultAgedBacterial ProteinsClarithromycinDrug Resistance, Multiple, BacterialFemaleGenotypeHumansIranMaleMetronidazoleAnti-Bacterial AgentsBacterial ProteinsClarithromycinMetronidazoleRNA, Ribosomal, 16SRNA, Ribosomal, 23STetracyclineantibiotic resistancecag pathogenicitygastric biopsiesHelicobacter pylorivacuolating cytotoxinvirulence genotyping.

Identifiers

PMID38984569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.