Evidence map›Paper›PMID 38984270›Full record

ArticleEnvironmental science. Nano2024

The pulmonary effects of nickel-containing nanoparticles: Cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms.

Yiqun Mo, Yue Zhang, Qunwei Zhang

Abstract read
In one paragraph

Article in Environmental science. Nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Iron Oxide-Based Magnetic Nanoparticles in Oral Infection Control.International journal of nanomedicine · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yiqun MoDepartment of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
Yue ZhangNorthwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Qunwei ZhangDepartment of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
Mechanisms underlying metal nanoparticle-induced lung injury and fibrosisR01HL147856 · NHLBI · UNIVERSITY OF LOUISVILLE · PI ZHANG, QUNWEI · 2019 to 2022
$1.6M
The role of microRNA miR-21 in nickel nanoparticles-induced MMPs productionR15ES023693 · NIEHS · UNIVERSITY OF LOUISVILLE · PI ZHANG, QUNWEI · 2014 to 2014
$450k
Mechanisms of carcinogenic effects of nickel nanoparticlesR21ES028911 · NIEHS · UNIVERSITY OF LOUISVILLE · PI ZHANG, QUNWEI · 2018 to 2019
$424k
NHLBI NIH HHS R01 HL147856NIEHS NIH HHS P30 ES030283NIEHS NIH HHS R15 ES023693NIEHS NIH HHS R21 ES028911
6 · The paper itself

Abstract

With the exponential growth of the nanotechnology field, the global nanotechnology market is on an upward track with fast-growing jobs. Nickel (Ni)-containing nanoparticles (NPs), an important class of transition metal nanoparticles, have been extensively used in industrial and biomedical fields due to their unique nanostructural, physical, and chemical properties. Millions of people have been/are going to be exposed to Ni-containing NPs in occupational and non-occupational settings. Therefore, there are increasing concerns over the hazardous effects of Ni-containing NPs on health and the environment. The respiratory tract is a major portal of entry for Ni-containing NPs; thus, the adverse effects of Ni-containing NPs on the respiratory system, especially the lungs, have been a focus of scientific study. This review summarized previous studies, published before December 1, 2023, on cytotoxic, genotoxic, and carcinogenic effects of Ni-containing NPs on humans, lung cells

Indexed as

Cell transformationDNA damageFibrosisHIF-1αInflammationLung injuryNickel and nickel compound nanoparticles

Identifiers

PMID38984270
PMCPMC11230653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.