Evidence map›Paper›PMID 38983966›Full record

ArticleFrontiers in ophthalmology2021

Choroidal Vascularity Index in CHM Carriers.

Dario Pasquale Mucciolo, Dario Giorgio, Myrta Lippera, Ilaria Passerini, Elisabetta Pelo, Francesca Cipollini, Andrea Sodi, Gianni Virgili, Fabrizio Giansanti, Vittoria Murro

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In one paragraph

Article in Frontiers in ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dario Pasquale MuccioloDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Dario GiorgioDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Myrta LipperaDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Ilaria PasseriniDepartment of Genetic Diagnosis, Careggi University Hospital, Florence, Italy.
Elisabetta PeloDepartment of Genetic Diagnosis, Careggi University Hospital, Florence, Italy.
Francesca CipolliniDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Andrea SodiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Gianni VirgiliDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Fabrizio GiansantiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Vittoria MurroDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To assess the choroidal structure using the Choroidal Vascularity Index (CVI) and analyse choroidal changes in choroideremia (CHM) carriers. Material and Methods: Female CHM carriers, genetically characterized, and a control group were recruited at the Eye Clinic of Careggi Teaching Hospital, Florence. The patients underwent a complete ophthalmic evaluation and retinal imaging. In particular, the Stromal Area (SA), Luminal Area (LA), Total Choroidal Area (TCA), CVI, and Subfoveal Choroidal Thickness (SFCT) were calculated for each eye using Optical Coherence Tomography (OCT) examinations. Results: Twelve eyes of 6 CHM carriers and 14 eyes of 7 age-matched controls were analysed. The mean SFCT was 270.9 ± 54.3μm in carriers and 281.4 ± 36.8μm in controls (p = 0.564); LA was 0.99 ± 0.25mm Conclusions: The CVI and CVI-related parameters (SA, LA, and TCA) do not differ between CHM female carriers and controls. These findings reveal a preserved choroidal vasculature in eyes with RPE impairment and support the primary role of RPE in the pathogenesis of CHM disease.

Indexed as

carriersCHMchoroidchoroideremiaCVIOCT

Identifiers

PMID38983966
PMCPMC11182189

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