Evidence map›Paper›PMID 38983958›Full record

ArticleWorld journal of gastroenterology2024

Effect and mechanism of Qingre Huashi decoction on drug-resistant

Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye, Xue-Zhi Zhang

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Prevalence ofWorld journal of gastroenterology · 2024
    Pooled it
  2. Research Status and Prospects ofGastroenterology research and practice · 2026
    Review
  3. Article
  4. The Potential Role ofMicroorganisms · 2025
    Review
  5. Frontiers in microbiology · 2025
    Review
  6. Jinghuaweikang capsule alleviatesFrontiers in cellular and infection microbiology · 2025
    Article
  7. Review
  8. International journal of molecular sciences · 2024
    Review
  9. Effect of SiHuangQingXinWan onFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miao-Miao LinDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Shan-Shan YangDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Qiu-Yue HuangDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Guang-Hui CuiDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Xiao-Fen JiaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Yao YangDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Zong-Ming ShiDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Hui YeDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Xue-Zhi ZhangDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

aimTo explore the effect and mechanism of QHD on clinically multidrug-resistant and strong biofilm-forming HP.

methodsIn this study, 12 HP strains were isolated

resultsHP could form biofilms of different degrees

conclusionQHD exerts bacteriostatic and bactericidal effects on HP, and reduces HP drug resistance by inhibiting HP biofilm formation, destroying its biofilm structure, inhibiting the expression of biofilm-related genes and efflux pump-related genes, enhancing HP metabolism, and activating AMP in HP.

Indexed as

Anti-Bacterial AgentsBiofilmsDrugs, Chinese HerbalHelicobacter InfectionsHelicobacter pyloriMicrobial Sensitivity TestsDrug Resistance, Multiple, BacterialGastroscopyHumansAnti-Bacterial AgentsDrugs, Chinese HerbalBiofilmDrug resistanceHelicobacter pyloriMetabolomicsQingre Huashi decoction

Identifiers

PMID38983958
PMCPMC11230061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.