ArticleFrontiers in veterinary science2024
Effects of hesperidin on the histological structure, oxidative stress, and apoptosis in the liver and kidney induced by NiCl
Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hesperidin attenuates gentamicin-induced nephrotoxicity: Association with SIRT3 and PAX2 expression, oxidative stress, and tubular injury.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Multi-omics and genetic prioritization identify candidate molecular links between micro- and nanoplastics-associated signatures and chronic kidney disease.Molecular diversity · 2026Article
- Effects of Hesperidin on the Intestinal Histological Structure, Goblet Cells, Tight Junction Proteins, and Nickel (NiClBiological trace element research · 2026Article
- Comparative study on the protective effects of Silybum marianum L. seeds and leaves against nickel chloride induced anemia, liver and kidney injury: an in vivo and in silico approach.Scientific reports · 2026Article
- Effect of NiCl2 Intake Through Respiratory Tract on Antioxidant Capacity, Lung, and Trace Element Content in Mice.Biological trace element research · 2025Article
- Article
- Effects of hesperidin and ascorbic acid combination on boar sperm quality during cryopreservation.Frontiers in veterinary science · 2025Article
- Renal Health Through Medicine-Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms.Nutrients · 2024Review
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Authors and funding
14 authors.
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Abstract
The aim of this study was to investigate the effect of hesperidin on the liver and kidney dysfunctions induced by nickel. The mice were divided into six groups: nickel treatment with 80 mg/kg, 160 mg/kg, 320 mg/kg hesperidin groups, 0.5% CMC-Na group, nickel group, and blank control group. Histopathological techniques, biochemistry, immunohistochemistry, and the TUNEL method were used to study the changes in structure, functions, oxidative injuries, and apoptosis of the liver and kidney. The results showed that hesperidin could alleviate the weight loss and histological injuries of the liver and kidney induced by nickel, and increase the levels of lactate dehydrogenase (LDH), alanine aminotransferase (GPT), glutamic oxaloacetic transaminase (GOT) in liver and blood urea nitrogen (BUN), creatinine (Cr) and N-acetylglucosidase (NAG) in kidney. In addition, hesperidin could increase the activities of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) in the liver and kidney, decrease the content of malondialdehyde (MDA) and inhibit cell apoptosis. It is suggested that hesperidin could help inhibit the toxic effect of nickel on the liver and kidney.
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