Evidence map›Paper›PMID 38983692›Full record

ArticleReproductive medicine and biology

Very severe oligozoospermia with AZFc microdeletion patients may affect intracytoplasmic sperm injection clinical outcomes: A propensity score matching analysis.

Huan Zhang, Huanzhu Li, Shujuan Ma, Shuoping Zhang, Wen Li, Yifan Gu, Erchen Zhang, Liang Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huan ZhangNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China.ORCID https://orcid.org/0009-0000-4102-4680
Huanzhu LiSchool of Medicine Hunan Normal University Changsha Hunan China.
Shujuan MaNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China.
Shuoping ZhangClinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC-Xiangya Changsha Hunan China.
Wen LiNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China.
Yifan GuNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China.
Erchen ZhangNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China.
Liang HuNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China.ORCID https://orcid.org/0000-0001-6984-834X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To explore whether spermatozoa from AZFc microdeletion patients affect their outcomes of intracytoplasmic sperm injection (ICSI). Methods: Eighty-five patients with AZFc microdeletion were recruited. A control group of one hundred and forty patients with severe oligozoospermia but without AZF microdeletion was selected using propensity score matching analysis with a 1:2 nearest neighbor algorithm ratio. The ICSI outcomes of the two groups were compared. Results: AZFc microdeletion had lower rates of normal fertilization (73% vs. 80%, Conclusion: If the sperm concentration is <1 million/mL, AZFc microdeletion do have a detrimental effect on most outcomes of ICSI.

Indexed as

azoospermia factorintracytoplasmic sperm injectionpropensity score matchingsevere oligozoospermiaY chromosome microdeletion

Identifiers

PMID38983692
PMCPMC11232045

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.