ArticleWorld journal of clinical cases2024
Association of total bilirubin with depression risk in adults with diabetes: A cross-sectional study.
Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Compromised hepatic bilirubin clearance drives depressive symptoms via regulating microglial engulfment of dendritic spines.Journal of neuroinflammation · 2026Article
- Association between abdominal muscle mass quantified by computed tomography and depression in middle-aged and older Korean men: a cross-sectional study of 2,877 cases.Frontiers in medicine · 2026Article
- Anxiety and Depression Among Hepatitis B Inpatients in Shenzhen, China: A Cross-Sectional Study.Alpha psychiatry · 2025Article
- A Novel Depression Risk Prediction Model Using NHANES Data With Mendelian Randomization Validation.Brain and behavior · 2025Article
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2 authors.
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Abstract
backgroundIndividuals with diabetes mellitus are more likely to experience depression, although most patients remain undiagnosed. The relation between total bilirubin and depression has been increasingly discussed, but limited studies have examined the association of total bilirubin with depression risk in adults with diabetes, which warrants attention.
aimTo investigate the association between total bilirubin levels and the risk of depression in adults with diabetes.
methodsThe study included adults with diabetes from the National Health and Nutrition Examination Survey 2007-2018. Depression was determined using the Patient Health Questionnaire-9. Multivariable logistic regression, propensity score-matched analysis and restricted cubic spline models were utilized to investigate the association between total bilirubin levels and depression risk in adults with diabetes.
resultsThe study included 4758 adults with diabetes, of whom 602 (12.7%) were diagnosed with depression. After adjusting for covariates, we found that diabetic adults with lower total bilirubin levels had a higher risk of depression (OR = 1.230, 95%CI: 1.006-1.503,
conclusionIn adults with diabetes, those with lower levels of total bilirubin were more likely to have depressive symptoms. Serum total bilirubin levels may be used as an additional indicator to assess depression risk in adults with diabetes.
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