Evidence map›Paper›PMID 38983069›Full record

ReviewFrontiers in ophthalmology2023

New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.

Abhilash Sawant, Aindrila Saha, Jacob Khoussine, Raunak Sinha, Mrinalini Hoon

Abstract readReview
In one paragraph

Review in Frontiers in ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abhilash SawantDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Aindrila SahaDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
Jacob KhoussineDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Raunak SinhaDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Mrinalini HoonDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The retinal neural circuit is intricately wired for efficient processing of visual signals. This is well-supported by the specialized connections between retinal neurons at both the functional and ultrastructural levels. Through 3D electron microscopic (EM) reconstructions of retinal neurons and circuits we have learnt much about the specificities of connections within the retinal layers including new insights into how retinal neurons establish connections and perform sophisticated visual computations. This mini-review will summarize the retinal circuitry and provide details about the novel insights EM connectomics has brought into our understanding of the retinal circuitry. We will also discuss unresolved questions about the retinal circuitry that can be addressed by EM connectomics in the future.

Indexed as

circuitelectron microscopyreconstructionretinasynapse

Identifiers

PMID38983069
PMCPMC11182165

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.