ArticleFrontiers in ophthalmology2023
Rod-cone signal interference in the retina shapes perception in primates.
Article in Frontiers in ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Rod + cone signal interference impairs mesopic motion discriminability in a model circuit.Journal of vision · 2026Article
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3 authors.
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Abstract
Linking the activity of neurons, circuits and synapses to human behavior is a fundamental goal of neuroscience. Meeting this goal is challenging, in part because behavior, particularly perception, often masks the complexity of the underlying neural circuits, and in part because of the significant behavioral differences between primates and animals like mice and flies in which genetic manipulations are relatively common. Here we relate circuit-level processing of rod and cone signals in the non-human primate retina to a known break in the normal seamlessness of human vision - a surprising inability to see high contrast flickering lights under specific conditions. We use electrophysiological recordings and perceptual experiments to identify key mechanisms that shape the retinal integration of rod- and cone-generated retinal signals. We then incorporate these mechanistic insights into a predicti\ve model that accurately captures the cancellation of rod- and cone-mediated responses and can explain the perceptual insensitivity to flicker.
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