Evidence map›Paper›PMID 38982998›Full record

ArticleFrontiers in ophthalmology2023

Initial experiences of switching to faricimab for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in an Asian population.

Farah N I Ibrahim, Kelvin Y C Teo, Tien-En Tan, Hiok Hong Chan, Priya R Chandrasekaran, Shu-Yen Lee, Anna C S Tan, Ranjana Mathur, Choi Mun Chan, Shaun S Sim and 3 more

Abstract read
In one paragraph

Article in Frontiers in ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Farah N I Ibrahim *Medical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Kelvin Y C Teo *Medical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Tien-En TanMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Hiok Hong ChanMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Priya R ChandrasekaranMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Shu-Yen LeeMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Anna C S TanMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Ranjana MathurMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Choi Mun ChanMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Shaun S SimMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Gavin Siew Wei TanMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Ian Y S YeoMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.
Chui Ming Gemmy CheungMedical Retina Department, Singapore National Eye Centre, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe the early experiences of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) whose treatment was switched to faricimab from other anti-vascular endothelial growth factor (VEGF) agents. Methods: This is a prospective cohort of eyes with nAMD and PCV that were previously treated with anti-VEGF agents other than faricimab. We evaluated visual acuity (VA), central subfield thickness (CST), macular volume (MV), pigment epithelial detachment (PED) height, and choroidal thickness (CT) after one administration of faricimab. Where present, fluid was further evaluated according to intraretinal fluid (IRF), subretinal fluid (SRF), or within PED. Results: Seventy-one eyes from 71 patients were included (45.07% PCV and 54.93% typical nAMD). The mean [standard deviation (± SD)] VA, CST, and MV improved from 0.50 logMAR (± 0.27 logMAR) to 0.46 logMAR (± 0.27 logMAR) ( Conclusions: In our case series of Asian nAMD patients, switching to faricimab was associated with a stable VA and meaningful anatomical improvements, particularly with typical nAMD subtypes.

Indexed as

ANG-2anti-vegffaricimabneovascular age-related macular degenerationpolypoidal choroidal vasculopathyswitch therapy

Identifiers

PMID38982998
PMCPMC11182304

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.