Evidence map›Paper›PMID 38982978›Full record

ReviewCancer biology & medicine2024

The role of reactive oxygen species in gastric cancer.

Yuqi Wang, Jingli Xu, Zhenjie Fu, Ruolan Zhang, Weiwei Zhu, Qianyu Zhao, Ping Wang, Can Hu, Xiangdong Cheng

Abstract readReview
In one paragraph

Review in Cancer biology & medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Mitochondrial Stress inAntioxidants (Basel, Switzerland) · 2026
    Review
  6. International journal of molecular sciences · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqi WangCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Jingli XuDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Zhenjie FuDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Ruolan ZhangDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Weiwei ZhuDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Qianyu ZhaoDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Ping WangCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Can HuDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.ORCID 0000-0002-8687-8310
Xiangdong ChengDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.ORCID 0000-0002-5099-490X

Funding

China Postdoctoral Science Foundation 2023M733563Healthy Zhejiang One Million People Cohort K-20230085Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2104Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2202National Natural Science Foundation of China 81903842National Natural Science Foundation of China 81973634National Natural Science Foundation of China 82074245National Natural Science Foundation of China 82304946Natural Science Foundation of Zhejiang Province LR21H280001Post-doctoral Innovative Talent Support Program BX2023375Program of Zhejiang Provincial TCM Sci-tech Plan 2018ZY006Program of Zhejiang Provincial TCM Sci-tech Plan 2020ZZ005Science and Technology Projects of Zhejiang Province 2019C03049The National Key Research and Development Program of China 2021YFA0910100Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer JBZX-202006
6 · The paper itself

Abstract

Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.

Indexed as

Reactive Oxygen SpeciesSignal TransductionStomach NeoplasmsAnimalsAntineoplastic AgentsHumansOxidative StressAntineoplastic AgentsReactive Oxygen Speciesantitumor therapyGastric cancernatural productspharmacologyreactive oxygen speciesROS

Identifiers

PMID38982978
PMCPMC11414220

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.