ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.
Abstract readMulticenter Study
In one paragraph
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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Who cites it
30 citing papers in PubMed.
- Emotional brain responses and pattern expressions in right temporal variant frontotemporal dementia.Journal of neurology · 2026Article
- Differential aspects of familiar people recognition disorders in right and left variants of semantic dementia: A critical review.Journal of neuropsychology · 2026Review
- Behavior determines times to care home admission and death in semantic dementia: Insights from a cohort of 90 cases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Comparing the value of dynamic versus static image-based tests of emotion recognition in neurodegenerative disease.Journal of neuropsychology · 2026Article
- Article
- Frontotemporal dementia with right temporal predominance: a clinical comparison with left-predominant FTD.Journal of neurology · 2026Article
- Social engagement and brain structure-informed cognitive domain trajectories in older adults: The National Health and Aging Trends Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Unifying Divergent Conceptions in Nonfluent/Agrammatic and Semantic Primary Progressive Aphasia.Brain sciences · 2026Review
- The presymptomatic and early manifestations of semantic dementia.Brain : a journal of neurology · 2026Article
- Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multimodal semantic knowledge of emotion concepts in frontotemporal dementia.medRxiv : the preprint server for health sciences · 2026Article
- Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes.Brain communications · 2026Article
- Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes?Frontiers in neuroscience · 2026Article
- Functional neuroanatomy of musical object processing in Alzheimer's disease and frontotemporal dementia.Brain communications · 2026Article
- Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.Communications medicine · 2025Review
- Distinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants.European journal of neurology · 2025Article
- Machine Learning Models of Voxel-Level [Annals of neurology · 2025Article
- Criminal Behavior in Frontotemporal Dementia: A Multimodal MRI Study.Human brain mapping · 2025Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- Neurodevelopmental Vulnerability in Alzheimer's Disease and Frontotemporal Dementia.European journal of neurology · 2025Article
Corrections and comments
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Authors and funding
47 authors.
Hulya UlugutAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.ORCID 0000-0002-5016-2505
Maxime BertouxLille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France.
Kyan YounesMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Maxime MontembeaultMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Giorgio G FumagalliDepartment of Neurology, University of Milan, Milan, Italy.
Bedia SamanciDepartment of Neurology, Istanbul University, Fatih, Istanbul, Turkey.
Ignacio Illán-GalaSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Gregory KuchcinskiLille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France.
Melanie LeroyLille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France.
Jennifer C ThompsonCerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.
Christopher KobyleckiDepartment of Neurology, Manchester Centre for Clinical Neurosciences NHS Foundation Trust, Salford, UK.
Alexander F SantilloClinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Elisabet EnglundDivision of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Maria Landqvist WaldöDivision of Clinical Sciences Helsingborg, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Lina RiedlSchool of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.
Jan Van den StockNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.
Mathieu VandenbulckeNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.
Rik VandenbergheDepartment of Neurology, University Hospital Leuven, Leuven, Belgium.
Robert LaforceClinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, Laval University, Quebec City, Canada.
Simon DucharmeDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
Peter S PressmanAnschutz Medical Campus, Behavioral Neurology Section, Department of Neurology, University of Colorado, Aurora, Colorado, USA.
Paulo CaramelliBehavioral and Cognitive Neurology Unit, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Leonardo Cruz de SouzaBehavioral and Cognitive Neurology Unit, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Leonel T TakadaCognitive and Behavioral Unit, Hospital das Clinicas, Department of Neurology, University of São Paulo Medical School, Pacaembu, São Paulo, Brazil.
Hakan GurvitDepartment of Neurology, Istanbul University, Fatih, Istanbul, Turkey.
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Janine Diehl-SchmidSchool of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.
Daniela GalimbertiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Florence PasquierLille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France.
Bruce L MillerMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.
Rik OssenkoppeleAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.
Wiesje M van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.
Frederik BarkhofAlzheimer Center Amsterdam, Department of Radiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.
Nick C FoxDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Virginia E SturmMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Toji MiyagawaDepartment of Neurology, Mayo Clinic, Rochester, Rochester, Minnesota, USA.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, Rochester, Minnesota, USA.
Bradley BoeveDepartment of Neurology, Mayo Clinic, Rochester, Rochester, Minnesota, USA.
Jonathan D RohrerDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, Rochester, Minnesota, USA.
Julie SnowdenCerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.
Jason D WarrenDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Katherine P RankinMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.
International rtvFTD Working Group
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MProgressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0MEmotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9MUnderstanding the role of TDP-43 in Alzheimers disease and FTLDR01AG037491 · NIA · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2024
$6.5MPrimary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7MAttention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0MMeasuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6MTraining program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9MPIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7MComputational Speech Analysis in Alzheimer's Disease and Other Neurocognitive Disorders (Supplement)K23AG063900 · NIA · UNIVERSITY OF COLORADO DENVER · PI PRESSMAN, PETER SCOTT · 2020 to 2024
$980kAssessment of hyperphosphorylated tau PET binding in primary progressive aphasiaR21NS094684 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2016 to 2017
$417kAlzheimer's Association AACSF-22-849085Alzheimer's Research UKAlzheimer's SocietyCNPqFondation France AlzheimerFondation PlaniolJosephs and Whitwell R01-AG37491Josephs and Whitwell R01-DC010367Josephs and Whitwell R21-NS94684Knut and Alice Wallenberg Foundation 2017-0383KU Leuven C24/18/095KU Leuven IDN/21/010Lund UniversityNIA NIH HHS K23 AG063900NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG029577NIA NIH HHS R01 AG037491NIA NIH HHS R01 AG052496NIA NIH HHS RF1 AG029577NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC010367NIHR UCLH Biomedical Research CentreNINDS NIH HHS R01 NS050915NINDS NIH HHS R21 NS094684NINDS NIH HHS RF1 NS050915Pressman K23 AG063900-01A1Rankin RF1-AG029577Royal National Institute for Deaf PeopleSequoia FundSwedish Alzheimer Foundation AF-980907Swedish Federal Government 2022-Projekt0080Swedish Research Council 2022-00775The National Brain Appeal RF1-AG029577
Abstract
introductionAlthough frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.
methodsRetrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.
resultsCommon symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.
Indexed as
Frontotemporal DementiaTemporal LobeAgedAtrophyFemaleHumansMaleMiddle AgedNeuropsychological TestsRetrospective Studiesemotion recognitionfrontotemporal dementiafrontotemporal lobar degenerationright anterior temporal lobesemantic dementiasocial cognition
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