Evidence map›Paper›PMID 38982799›Full record

ArticleJournal of the American Society for Mass Spectrometry2024

Quenching Trypsin Is Unnecessary in Filter-Based Bottom-Up Proteomics.

C Bruce Mousseau, Daniel D Hu, Sadie R Schultz, Matthew M Champion

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sadie R Schultz
Matthew M ChampionORCID 0000-0001-5927-5277

Funding

Role of N-alpha acetylation in mycobacterial secretion and virulenceR01AI106872 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2013 to 2024
$4.2M
Systematic Discovery and Analysis of Small Proteins and Small ORFs in MycobacteriaR01GM139277 · NIGMS · WADSWORTH CENTER · PI DERBYSHIRE, KEITH M, GRAY, TODD · 2020 to 2023
$2.2M
NIAID NIH HHS R01 AI106872NIGMS NIH HHS R01 GM139277
6 · The paper itself

Abstract

Quenching digestions in proteomics prior to analysis is routine in order to eliminate residual protease activity. Residual activity leads to overdigestion, nonspecific star-activity, and back-exchange in isotopic

Indexed as

ProteomicsTrypsinAnimalsFiltrationHumansHydrogen-Ion ConcentrationIsotope LabelingMass SpectrometryPeptide FragmentsPeptidesPeptide FragmentsPeptidesTrypsin

Identifiers

PMID38982799
PMCPMC11313428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.