Evidence map›Paper›PMID 38982765›Full record

ArticleSoft matter2024

Structural determinants of collapse by a monomolecular mimic of pulmonary surfactant at the physiological temperature.

Fazle R Dayeen, Bret A Brandner, Wei Bu, Stephen B Hall, David Gidalevitz

Abstract read
In one paragraph

Article in Soft matter, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fazle R DayeenDepartment of Physics, Center for Molecular Study of Condensed Soft Matter (μCoSM), Illinois Institute of Technology, Chicago, IL 60616, USA. gidalevitz@iit.edu.
Bret A BrandnerPulmonary & Critical Care Medicine, Oregon Health & Science University (OHSU), Portland, OR 97239-3098, USA. sbh@ohsu.edu.ORCID http://orcid.org/0000-0002-7278-0304
Wei BuNSF's ChemMatCARS, Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA.
Stephen B HallPulmonary & Critical Care Medicine, Oregon Health & Science University (OHSU), Portland, OR 97239-3098, USA. sbh@ohsu.edu.ORCID http://orcid.org/0000-0001-8870-2143
David GidalevitzDepartment of Physics, Center for Molecular Study of Condensed Soft Matter (μCoSM), Illinois Institute of Technology, Chicago, IL 60616, USA. gidalevitz@iit.edu.ORCID http://orcid.org/0000-0002-3620-780X

Funding

Mechanisms of Pulmonary Surfactant FunctionR01HL136734 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HALL, STEPHEN B · 2018 to 2020
$1.6M
Therapeutic SurfactantsR56HL130130 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HALL, STEPHEN B · 2016 to 2016
$415k
NHLBI NIH HHS R01 HL136734NHLBI NIH HHS R56 HL130130
6 · The paper itself

Abstract

Pulmonary surfactant forms a thin film on the liquid that lines the alveolar air-sacks. When compressed by the decreasing alveolar surface area during exhalation, the films avoid collapse from the air/water interface and reduce surface tension to exceptionally low levels. To define better the structure of compressed films that determines their susceptibility to collapse, we measured how cholesterol affects the structure and collapse of dipalmitoyl phosphatidylcholine (DPPC) monolayers at physiological temperatures. Grazing incidence X-ray diffraction (GIXD) and grazing incidence X-ray off-specular scattering (GIXOS) established the lateral and transverse structures of films on a Langmuir trough at a surface pressure of 45 mN m

Indexed as

1,2-DipalmitoylphosphatidylcholineCholesterolPulmonary SurfactantsTemperature1,2-DipalmitoylphosphatidylcholineCholesterolPulmonary Surfactants

Identifiers

PMID38982765
PMCPMC12854728

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.