Evidence map›Paper›PMID 38982716›Full record

ArticlePharmacology research & perspectives2024

Has the human biological interaction with SARS-CoV2 variants entered a pliant "Faustian bargain"?

Richard J Head, Marko Popovic, Jennifer H Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard J HeadDrug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0002-1196-0926
Marko PopovicInstitute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0003-0934-5550
Jennifer H MartinCentre for Drug Repurposing and Medicines Research, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.ORCID https://orcid.org/0000-0002-8614-0199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesize that a "Faustian bargain"-the trading of increased SARS-CoV2 viral infection with a concurrent potential for prevention of life-threatening lower lung infection explains the previous and future morbidity and mortality from COVID-19. Further, this trade-off is made feasible by fundamental principles of thermodynamics and receptor affinity.

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2HumansSpike Glycoprotein, CoronavirusThermodynamicsACE2 protein, humanAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID‐19Gibbs free energythermodynamics

Identifiers

PMID38982716
PMCPMC11233407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.