Observational studyJournal of orthopaedic surgery and research2024
The association between osteoporosis and frailty: a cross-sectional observational study and mendelian randomization analysis.
Observational study in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Beyond static frailty: longitudinal trajectories, nonlinear associations, and muscle strength mediation in osteoporosis risk.Journal of global health · 2026Article
- Associations between controlling nutritional status and mortality in osteoporosis: evidence from NHANES, 2005-2018.Calcified tissue international · 2026Observational
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Diagnostic yield and number needed to screen for cervical and concomitant spinal injuries in geriatric head trauma.Brain & spine · 2026Article
- Circulating microRNAs miR-21-5p, miR-23a-3p and miR-26a-5p reflect clinical and molecular features of aging.Scientific reports · 2025Article
- Social isolation to depression: the chain mediating effect of sleep duration and frailty-evidence from a Chinese nationwide cross-sectional study.BMC geriatrics · 2025Article
- Prognostic impact of preoperative osteopenia in elderly patients with lung cancer.World journal of surgical oncology · 2025Article
- Knowledge, Beliefs and Preventive Practices Regarding Osteoporosis: A Cross-Sectional Study in Community Pharmacies in Tunis.Nutrients · 2025Article
- Mendelian randomization reveals contrasting effects of immune signaling molecules on bone and articular cartilage malignancies.Discover oncology · 2025Article
- Mediation of the frailty index, the relationship between sleep duration and chronic pain in different body regions: insights from the CHARLS cross-sectional study.Journal of orthopaedic surgery and research · 2025Article
- Opportunistic computed tomography (CT) assessment of osteoporosis in patients undergoing transcatheter aortic valve replacement (TAVR).Archives of osteoporosis · 2025Article
- Frailty and lived experiences in older adults with osteoporosis: protocol for a convergent mixed-methods study.Frontiers in medicine · 2025Article
- Physical Activity and Frailty Are Impaired in Older Adults with Benign Paroxysmal Positional Vertigo.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundOsteoporosis and frailty are two common features in the elderly population. Despite many review articles mentioning the association between osteoporosis and frailty, there is a lack of original research directly investigating their relationship. Therefore, this study was conducted to examine the correlation between osteoporosis and frailty.
methodsWe conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES), using logistic regression analysis to assess the association of osteoporosis with the frailty index. In addition, we further explored the causal relationship between them using Mendelian randomization (MR) study.
resultsIn the cross-sectional study, 19,091 non-frailty participants and 5878 frailty participants were included in this study. We observed a significant positive association between osteoporosis and frailty after adjusting for demographic characteristics, body mass index (BMI), smoking, and alcohol use (OR = 1.454, 95% CI [1.142,1.851], P = 0.003). Moreover, the MR study showed a bidirectional causal relationship between osteoporosis and frailty. When osteoporosis was used as an exposure factor, the frailty pooled OR value calculated utilizing the inverse variance weighted (IVW) method was 2.81 (95% CI [1.69, 4.68], P = 6.82 × 10
conclusionsOsteoporosis was positively correlated with frailty, and the results remained robust after adjusting for covariates. Further, MR studies have shown a bidirectional causal relationship between osteoporosis and frailty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.