Evidence map›Paper›PMID 38982460›Full record

ArticleBMC biology2024

AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity.

Yanke Jiang, Yingzhe Yue, Chongchong Lu, Muhammad Zunair Latif, Haifeng Liu, Zhaoxu Wang, Ziyi Yin, Yang Li, Xinhua Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. APlants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanke JiangState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Yingzhe YueState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Chongchong LuState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Muhammad Zunair LatifState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Haifeng LiuState Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Taian, Shandong, 271018, China.
Zhaoxu WangState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Ziyi YinState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Yang LiState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China.
Xinhua DingState Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai an, Shandong, 271018, China. xhding@sdau.edu.cn.ORCID http://orcid.org/0000-0002-6510-5992

Funding

Key Technologies Research and Development Program 2022YFD1401500Key Technologies Research and Development Program 2022YFD1402100Key Technology Research and Development Program of Shandong Province 2021TZXD007-04-4Key Technology Research and Development Program of Shandong Province 2022TZXD0025Major Basic Research Project of Natural Science Foundation of Shandong Province ZR2022ZD23National Natural Science Foundation 32072500National Natural Science Foundation 32272557Taishan Scholar Foundation of Shandong Province NO.tstp20221117
6 · The paper itself

Abstract

Pre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiological processes in plants. Human NHP2L binds to U4 snRNA during spliceosome assembly; it is involved in RNA splicing and mediates the development of human tumors. However, no ortholog has yet been identified in plants. Therefore, we report At4g12600 encoding the ortholog NHP2L protein, and AtSNU13 associates with the component of the spliceosome complex; the atsnu13 mutant showed compromised resistance in disease resistance, indicating that AtSNU13 is a positive regulator of plant immunity. Compared to wild-type plants, the atsnu13 mutation resulted in altered splicing patterns for defense-related genes and decreased expression of defense-related genes, such as RBOHD and ALD1. Further investigation shows that AtSNU13 promotes the interaction between U4/U6.U5 tri-snRNP-specific 27 K and the motif in target mRNAs to regulate the RNA splicing. Our study highlights the role of AtSNU13 in regulating plant immunity by affecting the pre-mRNA splicing of defense-related genes.

Indexed as

ArabidopsisArabidopsis ProteinsPlant ImmunityRNA PrecursorsRNA SplicingGene Expression Regulation, PlantNADPH OxidasesPlant DiseasesSpliceosomesTransaminasesAGD2-LIKE DEFENSE RESPONSE PROTEIN1, ArabidopsisArabidopsis ProteinsAT5G47910 protein, ArabidopsisNADPH OxidasesRNA PrecursorsTransaminasesEffector-triggered immunityPattern-triggered immunityPlant immunityPost-transcriptional regulationRNA splicingSpliceosome component

Identifiers

PMID38982460
PMCPMC11234627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.