ArticleThe journal of headache and pain2024
Children and adolescents with primary headaches exhibit altered sensory profiles - a multi-modal investigation.
Article in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effects of Sleep Deprivation and Neuromodulatory Interventions on Olfactory-Related Brain Function.Brain topography · 2026Trial
- Multidisciplinary management of headache in developmental age: effects on school performance, quality of life, and therapeutic perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Temporomandibular disorders in children and adolescents: an underexplored condition in need of developmentally informed diagnostic guidance.Pain management · 2026Review
- Consultation Lag and Early Improvement in Pediatric Daily Headache: A Retrospective Observational Study.Medical sciences (Basel, Switzerland) · 2026Observational
- Olfactory abnormalities in patients with migraine: a narrative review of a symptom commonly overlooked by neurologists.Journal of oral & facial pain and headache · 2025Review
- Review
- Translation, Validation, and Cross-Cultural Adaptation of the Patient and Observer Scar Assessment Scale (POSAS) into Persian.The archives of bone and joint surgery · 2025Article
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Authors and funding
8 authors.
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Abstract
backgroundPediatric headache is an increasing medical problem that has adverse effects on children's quality of life, academic performance, and social functioning. Children with primary headaches exhibit enhanced sensory sensitivity compared to their healthy peers. However, comprehensive investigations including multimodal sensory sensitivity assessment are lacking. This study aimed to compare sensory sensitivity of children with primary headaches with their healthy peers across multiple sensory domains.
methodsThe study included 172 participants aged 6 to 17 years (M = 13.09, SD = 3.02 years; 120 girls). Of these 80 participants were patients with migraine, 23 were patients with tension-type headache, and 69 were healthy controls. The following sensory measures were obtained: Mechanical Detection Threshold (MDT), Mechanical Pain Threshold (MPT), Mechanical Pain Sensitivity (MPS), detection and pain threshold for Transcutaneous Electrical Nerve Stimulation (TENS), olfactory and intranasal trigeminal detection threshold, and odor identification ability. Sensory sensitivity was compared between groups with a series of Kruskal-Wallis tests. Binomial regression models were used to compare the relative utility of sensory sensitivity measures in classifying participants into patients and healthy controls, as well as into patients with migraine and tension-type headache.
resultsPatients with migraine had lower MPT measured at the forearm than patients with tension-type headaches and healthy controls. MPS was higher in patients with migraine than in healthy controls. All patients with headaches had lower detection threshold of TENS and higher olfactory sensitivity. Healthy controls showed increased intranasal trigeminal sensitivity. Scores in MPS, TENS, and olfactory and trigeminal thresholds were significantly predicting presence of primary headaches. Additionally, scores in MPT, olfactory and trigeminal threshold were positive predictors of type of headache.
conclusionsChildren with primary headaches exhibit different sensory profiles than healthy controls. The obtained results suggest presence of increased overall, multimodal sensitivity in children with primary headaches, what may negatively impact daily functioning and contribute to further pain chronification.
trial registrationThe study was registered in the German Registry of Clinical Trials (DRKS) DRKS00021062.
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