Evidence map›Paper›PMID 38982000›Full record

Trial reportNeurocritical care2025

Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial.

Carita Hollmén, Riitta Parkkola, Victor Vorobyev, Jani Saunavaara, Ruut Laitio, Olli Arola, Marja Hynninen, Minna Bäcklund, Juha Martola, Emmi Ylikoski and 6 more

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00879892 (Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00879892 phase2completednot on this map

Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients

TypeinterventionalSponsorTurku University HospitalRan2009 to 2014Enrolled110ConditionsIschemic Brain InjuryArmsxenon, Hypothermia
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carita Hollmén *Department of Radiology, Turku University Hospital, University of Turku, Turku, Finland.
Riitta Parkkola *Department of Radiology, Turku University Hospital, University of Turku, Turku, Finland.
Victor VorobyevDepartment of Radiology, Turku University Hospital, University of Turku, Turku, Finland.
Jani SaunavaaraDepartment of Medical Physics, Turku University Hospital, University of Turku, Turku, Finland.
Ruut LaitioDivision of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, POB 52, 20521, Turku, Finland.
Olli ArolaDivision of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, POB 52, 20521, Turku, Finland.
Marja HynninenDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Minna BäcklundDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Juha MartolaDepartment of Radiology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Emmi YlikoskiDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Risto O RoineDivision of Clinical Neurosciences, Turku University Hospital, University of Turku, Turku, Finland.
Marjaana TiainenDepartment of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Harry ScheininDivision of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, POB 52, 20521, Turku, Finland.
Mervyn MazeCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.
Tero VahlbergDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
Timo T LaitioDivision of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, POB 52, 20521, Turku, Finland. timo.laitio@varha.fi.ORCID 0000-0002-2617-9358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe have earlier reported that inhaled xenon combined with hypothermia attenuates brain white matter injury in comatose survivors of out-of-hospital cardiac arrest (OHCA). A predefined secondary objective was to assess the effect of inhaled xenon on the structural changes in gray matter in comatose survivors after OHCA.

methodsPatients were randomly assigned to receive either inhaled xenon combined with target temperature management (33 °C) for 24 h (n = 55, xenon group) or target temperature management alone (n = 55, control group). A change of brain gray matter volume was assessed with a voxel-based morphometry evaluation of high-resolution structural brain magnetic resonance imaging (MRI) data with Statistical Parametric Mapping. Patients were scheduled to undergo the first MRI between 36 and 52 h and a second MRI 10 days after OHCA.

resultsOf the 110 randomly assigned patients in the Xe-Hypotheca trial, 66 patients completed both MRI scans. After all imaging-based exclusions, 21 patients in the control group and 24 patients in the xenon group had both scan 1 and scan 2 available for analyses with scans that fulfilled the quality criteria. Compared with the xenon group, the control group had a significant decrease in brain gray matter volume in several clusters in the second scan compared with the first. In a between-group analysis, significant reductions were found in the right amygdala/entorhinal cortex (p = 0.025), left amygdala (p = 0.043), left middle temporal gyrus (p = 0.042), left inferior temporal gyrus (p = 0.008), left parahippocampal gyrus (p = 0.042), left temporal pole (p = 0.042), and left cerebellar cortex (p = 0.005). In the remaining gray matter areas, there were no significant changes between the groups.

conclusionsIn comatose survivors of OHCA, inhaled xenon combined with targeted temperature management preserved gray matter better than hypothermia alone. CLINICAL

trial registrationClinicalTrials.gov: NCT00879892.

Indexed as

ComaGray MatterHypothermia, InducedNeuroprotective AgentsOut-of-Hospital Cardiac ArrestXenonAdministration, InhalationAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroprotective AgentsXenonGray matter injuryNeuroprotectionOut-of-hospital cardiac arrestTargeted temperature managementVoxel-based morphometryXenon

Identifiers

PMID38982000

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.