Evidence map›Paper›PMID 38981971›Full record

ArticleBehavior genetics2024

Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling.

Tanya B Horwitz, Katerina Zorina-Lichtenwalter, Daniel E Gustavson, Andrew D Grotzinger, Michael C Stallings

Abstract read
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In one paragraph

Article in Behavior genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Tanya B HorwitzInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St., Boulder, CO, 80303, USA. tanya.horwitz@colorado.edu.ORCID 0000-0001-8031-3944
Katerina Zorina-LichtenwalterInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St., Boulder, CO, 80303, USA.ORCID 0000-0003-4329-4961
Daniel E GustavsonInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St., Boulder, CO, 80303, USA.ORCID 0000-0002-1470-4928
Andrew D GrotzingerInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St., Boulder, CO, 80303, USA.ORCID 0000-0001-7852-9244
Michael C StallingsInstitute for Behavioral Genetics, University of Colorado Boulder, 1480 30th St., Boulder, CO, 80303, USA.ORCID 0000-0002-8231-9159

Funding

Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
Dissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3M
Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk SampleR01DA053693 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Christian J Hopfer, Michael Craig Stallings · 2022 to 2026
$3.2M
National Institute of Aging RF1 MH120219NIDA NIH HHS R01 DA053693NIDA NIH HHS T32 DA017637NIMH NIH HHS R01 MH120219
6 · The paper itself

Abstract

Externalizing behaviors encompass manifestations of risk-taking, self-regulation, aggression, sensation-/reward-seeking, and impulsivity. Externalizing research often includes substance use (SUB), substance use disorder (SUD), and other (non-SUB/SUD) "behavioral disinhibition" (BD) traits. Genome-wide and twin research have pointed to overlapping genetic architecture within and across SUB, SUD, and BD. We created single-factor measurement models-each describing SUB, SUD, or BD traits-based on mutually exclusive sets of European ancestry genome-wide association study (GWAS) statistics exploring externalizing variables. We then assessed the partitioning of genetic covariance among the three facets using correlated factors models and Cholesky decomposition. Even when the residuals for indicators relating to the same substance were correlated across the SUB and SUD factors, the two factors yielded a large correlation (r

Indexed as

Genome-Wide Association StudyImpulsive BehaviorLatent Class AnalysisSubstance-Related DisordersFemaleGenetic Predisposition to DiseaseGenomicsHumansMaleModels, GeneticPhenotypeRisk-TakingBehavioral geneticsExternalizingGenomic SEMSubstance use

Identifiers

PMID38981971

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.