Evidence map›Paper›PMID 38981881›Full record

Trial reportSurgical endoscopy2024

Long-term outcomes of laparoscopic versus open distal gastrectomy for patients with advanced gastric cancer in North China: a multicenter randomized controlled trial.

Jiadi Xing, Jun Cai, Xiaohui Wang, Nengwei Zhang, Dali An, Fei Li, Ming Cui, Lei Niu, Chongchong Gao, Qing Fan and 4 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02464215 (Comparison of the Laparoscopy-Assisted Distal Gastrectomy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02464215 naunknown statusnot on this map

Comparison of the Laparoscopy-Assisted Distal Gastrectomy(LADG) and Open Distal Gastrectomy(ODG) for Locally Advanced Gastric Cancer

TypeinterventionalSponsorPeking University Cancer Hospital & InstituteRan2014 to 2020Enrolled440ConditionsGastric CancerArmsopen surgery, laparoscopic surgery
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiadi Xing *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, Beijing, China.
Jun Cai *Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xiaohui Wang *Department of General Surgery, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.
Nengwei ZhangDepartment of General Surgery, School of Clinical Medicine, Peking University Ninth, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Dali AnDepartment of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Fei LiDepartment of General Surgery, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.
Ming CuiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, Beijing, China.
Lei NiuDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Chongchong GaoDepartment of General Surgery, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.
Qing FanDepartment of General Surgery, School of Clinical Medicine, Peking University Ninth, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Shulin RenDepartment of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zhongtao ZhangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. zhangzht@ccmu.edu.cn.
Xiangqian SuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Surgery IV, Beijing Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing, China. suxiangqian@bjmu.edu.cn.ORCID 0000-0002-0667-8141
SWEET trial group

Funding

Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZYLX202116Beijing Natural Science Foundation no. 5202008National Natural Science Foundation of China 82173218National Natural Science Foundation of China nos. 82171720
6 · The paper itself

Abstract

backgroundLaparoscopic distal gastrectomy (LDG) has become a common procedure for treating advanced gastric cancer (AGC) in China. However, there is uncertainty regarding its oncological outcomes compared to open distal gastrectomy (ODG). This study aims to compare the 3-year disease-free survival (DFS) rates among patients who underwent surgery for AGC in northern China.

methodsA multicenter, non-inferiority, open-label, parallel, randomized clinical trial was conducted to evaluate patients with AGC who were eligible for distal gastrectomy at five tertiary hospitals in North China. In this trial, patients were randomly assigned preoperatively to receive either LDG or ODG in a 1:1 allocation ratio. The primary endpoint was postoperative morbidity and mortality within 30 days and the secondary endpoint was the 3-year DFS rate. This trial has been registered at ClinicalTrials.gov (Identifier: NCT02464215).

resultsA total of 446 patients were randomly allocated to LDG (n = 223) or ODG group (n = 223) between March 2014 and August 2017. After screening, a total of 214 patients underwent the open surgical approach, while 216 patients underwent laparoscopic surgery. The 3-year DFS rate was 85.9% for the LDG group and 84.72% for the ODG group, with no significant statistical difference (Hazard ratio 1.12; 95% CI 0.68-1.84, P = 0.65). Body mass index (BMI) < 25 kg/m

conclusionsIn comparison to ODG, LDG with D2 lymphadenectomy yielded similar outcomes in terms of 3-year DFS rates among patients diagnosed with AGC.

Indexed as

GastrectomyLaparoscopyStomach NeoplasmsAdultAgedChinaDisease-Free SurvivalFemaleHumansMaleMiddle AgedPostoperative ComplicationsTreatment OutcomeAdvanced gastric cancerBody mass indexDisease-free survivalDistal gastrectomyLaparoscopy

Identifiers

PMID38981881
PMCPMC11362494

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.