Evidence map›Paper›PMID 38981876›Full record

ArticleJournal of bone and mineral metabolism2024

Deletion of Bmal1 in aggrecan-expressing cells leads to mouse temporomandibular joint osteoarthritis.

Lifan Liao, Lin Yang, Yu Li, Jiale Hu, Huang Lu, Huan Liu, Jiahao Huang, Longlong He, Zhaoli Meng, Jianfei Liang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of bone and mineral metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lifan Liao *Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Lin Yang *Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Yu LiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Jiale HuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Huang LuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Huan LiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Jiahao HuangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Longlong HeKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Zhaoli MengKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Jianfei LiangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Di ChenDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen, 518055, China.
Qin ZhouKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.
Xiaofeng Chang *Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China. changxf@mail.xjtu.edu.cn.
Shufang Wu *Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. sfwu002829@xjtufh.edu.cn.ORCID http://orcid.org/0000-0002-0953-9147

Funding

National Natural Science Foundation of China 81700997Xi'an Innovation Ability Strong Foundation Program - Medical Research Project 21YXYJ0124
6 · The paper itself

Abstract

introductionArticular cartilage is the major affected tissue during the development of osteoarthritis (OA) in temporomandibular joint (TMJ). The core circadian rhythm molecule Bmal1 regulates chondrocyte proliferation, differentiation and apoptosis; however, its roles in condylar cartilage function and in TMJ OA have not been fully elucidated. MATERIALS AND

methodsTMJ OA mouse model was induced by unilateral anterior crossbite (UAC) and Bmal1 protein expression in condylar cartilage were examined by western blot analysis. To determine the role of Bmal1 in TMJ OA, we generated cartilage-specific Bmal1 conditional knockout (cKO) mice (Bmal1

resultsBmal1 expression was reduced in condylar cartilage in a TMJ OA mouse model induced by UAC. The Bmal1 cKO mice displayed decreased cartilage matrix synthesis, reduced chondrocyte proliferation, increased chondrocyte hypertrophy and apoptosis as well as the upregulation of YAP expression in TMJ condylar cartilage.

conclusionsWe demonstrated that Bmal1 was essential for TMJ tissue homeostasis and loss-of-function of Bmal1 in chondrocytes leads to the development of TMJ OA.

Indexed as

AggrecansARNTL Transcription FactorsCartilage, ArticularChondrocytesOsteoarthritisTemporomandibular JointAnimalsApoptosisCell ProliferationDisease Models, AnimalGene DeletionMaleMiceMice, KnockoutAggrecansARNTL Transcription FactorsBmal1 protein, mouseBmal1ChondrocytesOsteoarthritisTemporomandibular jointYAP

Identifiers

PMID38981876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.