Evidence map›Paper›PMID 38981849›Full record

ArticlePhysiological reports2024

Sex differences in cardiac transcriptomic response to neonatal sleep apnea.

Emily C Cheung, Anna Nilsson, Ian Venter, Grant Kowalik, Caitlin Ribeiro, Jeannette Rodriguez, Kiralee Kuraoka, Rebekah Russo, Joan B Escobar, Bridget R Alber and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emily C CheungDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.ORCID 0000-0002-7642-2950
Anna NilssonDepartment of Anatomy, Biochemistry & Physiology, University of Hawaii, Honolulu, Hawaii, USA.
Ian VenterDepartment of Anatomy, Biochemistry & Physiology, University of Hawaii, Honolulu, Hawaii, USA.
Grant KowalikDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.
Caitlin RibeiroDepartment of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia, USA.
Jeannette RodriguezDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.
Kiralee KuraokaDepartment of Anatomy, Biochemistry & Physiology, University of Hawaii, Honolulu, Hawaii, USA.
Rebekah RussoDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.
Joan B EscobarDepartment of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia, USA.
Bridget R AlberDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.
David MendelowitzDepartment of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia, USA.ORCID 0000-0001-7107-1832
Matthew W KayDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.ORCID 0000-0003-2756-5055
Kathryn J SchunkeDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia, USA.ORCID 0000-0002-0815-8457

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Scalable platform for optimizing human cardiac tissue engineering via optical pacing and on-demand oxygenationR01HL144157 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI ENTCHEVA, EMILIA, KAY, MATTHEW W. · 2019 to 2022
$2.8M
Hypothalamic neuron activation to blunt myocardial remodeling during chronic sleep apneaR01HL146169 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI KAY, MATTHEW W. · 2019 to 2022
$2.6M
Restoration of Cardiac Parasympathetic Activity in Heart FailureR01HL133862 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI MENDELOWITZ, DAVID · 2016 to 2019
$1.8M
American Heart Association (AHA) 18CDA34080353HHS | National Institutes of Health (NIH) HL144157HHS | National Institutes of Health (NIH) HL146169HHS | National Institutes of Health (NIH) HL147279HHS | National Institutes of Health (NIH) UL1TR001876NHLBI NIH HHS R01 HL133862NHLBI NIH HHS R01 HL144157NHLBI NIH HHS R01 HL146169NHLBI NIH HHS T32 HL115505
6 · The paper itself

Abstract

Pediatric obstructive sleep apnea poses a significant health risk, with potential long-term consequences on cardiovascular health. This study explores the dichotomous nature of neonatal cardiac response to chronic intermittent hypoxia (CIH) between males and females, aiming to fill a critical knowledge gap in the understanding of sex-specific cardiovascular consequences of sleep apnea in early life. Neonates were exposed to CIH until p28 and underwent comprehensive in vivo physiological assessments, including whole-body plethysmography, treadmill stress-tests, and echocardiography. Results indicated that male CIH rats weighed 13.7% less than age-matched control males (p = 0.0365), while females exhibited a mild yet significant increased respiratory drive during sleep (93.94 ± 0.84 vs. 95.31 ± 0.81;p = 0.02). Transcriptomic analysis of left ventricular tissue revealed a substantial sex-based difference in the cardiac response to CIH, with males demonstrating a more pronounced alteration in gene expression compared to females (5986 vs. 3174 genes). The dysregulated miRNAs in males target metabolic genes, potentially predisposing the heart to altered metabolism and substrate utilization. Furthermore, CIH in males was associated with thinner left ventricular walls and dysregulation of genes involved in the cardiac action potential, possibly predisposing males to CIH-related arrhythmia. These findings emphasize the importance of considering sex-specific responses in understanding the cardiovascular implications of pediatric sleep apnea.

Indexed as

Animals, NewbornSex CharacteristicsTranscriptomeAnimalsFemaleHeartHypoxiaMaleMicroRNAsRatsRats, Sprague-DawleySex FactorsSleep Apnea SyndromesMicroRNAsautonomic imbalancecardiac miRNA expressioncardiac remodelingchronic intermittent hypoxiaCIHtranscription

Identifiers

PMID38981849
PMCPMC11233197

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.