ArticleOccupational and environmental medicine2024
Ovarian cancer deaths attributable to asbestos exposure in Lombardy (Italy) in 2000-2018.
Article in Occupational and environmental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Burden of Ovarian Cancer in China Attributable to Asbestos Exposure During 1990-2021 and the Projections Through 2050.International journal of women's health · 2026Article
- Engaging Social Stakeholders in National Asbestos Research for Public Health: An Italian Experience.Annals of global health · 2025Article
- Global trend analysis and risk evolution of asbestos-related ovarian cancer: a population-based study and future prediction (1990-2021).Frontiers in public health · 2025Article
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Authors and funding
9 authors.
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Abstract
objectivesWe aimed to estimate the fraction of deaths from ovarian cancer attributable to asbestos exposure in Lombardy Region, Italy, using a novel approach that exploits the fact that ovarian cancer asbestos exposure is associated with pleural cancer and other risk factors for breast cancer.
methodsThis ecological study is based on the Italian National Institute of Statistics mortality data. We formulate a trivariate Bayesian joint disease model to estimate the attributable fraction (AF) and the number of ovarian cancer deaths attributable to asbestos exposure from the geographic distribution of ovarian, pleural and breast cancer mortality at the municipality level from 2000 to 2018. Expected deaths and standardised mortality ratios were calculated using regional rates.
resultsWe found shared dependencies between ovarian and pleural cancer, which capture risk factors common to the two diseases (asbestos exposure), and a spatially structured clustering component shared between ovarian and breast cancer, capturing other risk factors. Based on 10 462 ovarian cancer deaths, we estimated that 574 (95% credibility interval 388-819) were attributable to asbestos (AF 5.5%; 95% credibility interval 3.7-7.8). AF reaches 34%-47% in some municipalities with known heavy asbestos pollution.
conclusionsThe impact of asbestos on ovarian cancer occurrence can be relevant, particularly in areas with high asbestos exposure. Estimating attributable cases was possible only by using advanced Bayesian modelling to consider other risk factors for ovarian cancer. These findings are instrumental in tailoring public health surveillance programmes and implementing compensation and prevention policies.
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