Evidence map›Paper›PMID 38981655›Full record

ArticleRNA (New York, N.Y.)2024

Structural idiosyncrasies of glycyl T-box riboswitches among pathogenic bacteria.

Nikoleta Giarimoglou, Adamantia Kouvela, Jinwei Zhang, Vassiliki Stamatopoulou, Constantinos Stathopoulos

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikoleta GiarimoglouDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-4746-2187
Adamantia KouvelaDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-1042-2349
Jinwei ZhangLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.ORCID 0000-0002-2114-173X
Vassiliki StamatopoulouDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-4900-5796
Constantinos StathopoulosDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece cstath@med.upatras.gr.ORCID 0000-0002-5699-4118

Funding

Noncoding RNA structures and interactions in cellular stress responses and immunityZIADK075136 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI ZHANG, JINWEI · 2016 to 2025
$23.2M
Intramural NIH HHS ZIA DK075136
6 · The paper itself

Abstract

T-box riboswitches are widespread bacterial regulatory noncoding RNAs that directly interact with tRNAs and switch conformations to regulate the transcription or translation of genes related to amino acid metabolism. Recent studies in Bacilli have revealed the core mechanisms of T-boxes that enable multivalent, specific recognition of both the identity and aminoacylation status of the tRNA substrates. However, in-depth knowledge on a vast number of T-boxes in other bacterial species remains scarce, although a remarkable structural diversity, particularly among pathogens, is apparent. In the present study, analysis of T-boxes that control the transcription of glycyl-tRNA synthetases from four prominent human pathogens revealed significant structural idiosyncrasies. Nonetheless, these diverse T-boxes maintain functional T-box:tRNA

Indexed as

Nucleic Acid ConformationRiboswitchRNA, BacterialBacteriaBase SequenceGene Expression Regulation, BacterialGlycine-tRNA LigaseHumansRNA, TransferRNA, Transfer, GlyGlycine-tRNA LigaseRiboswitchRNA, BacterialRNA, TransferRNA, Transfer, Glyglycyl-tRNA synthetasepathogenic bacteriaT-box riboswitchtranscription regulationtRNA

Identifiers

PMID38981655
PMCPMC11404447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.