ArticleOpen biology2024
Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis.
Article in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease.Mucosal immunology · 2026Article
- Immunohistological characterization of equine synovial tissue in metacarpophalangeal joints of different ages and osteoarthritis status.Osteoarthritis and cartilage open · 2026Article
- Local Circadian Clocks Are Desynchronized From the Central Circadian Pacemaker in a Mouse Model of Inflammatory Arthritis.ACR open rheumatology · 2026Article
- Sleep quality, duration, and multi-trajectories as predictors of rheumatoid arthritis: evidence from the english longitudinal study of ageing.Arthritis research & therapy · 2026Article
- Article
- Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation.Scientific reports · 2025Article
- Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications.Frontiers in immunology · 2025Review
- Targeting fibroblast activation protein in rheumatoid arthritis: from molecular imaging to precision therapeutics.Frontiers in immunology · 2025Review
- Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis.Open biology · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role of FLS circadian clock function in directing rhythmic joint inflammation in a murine model of inflammatory arthritis. We demonstrate FLS time-of-day-dependent gene expression is attenuated in arthritic joints, except for a subset of disease-modifying genes. The deletion of essential clock gene
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Registered trials
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