ArticleCell systems2024
Signal integration and adaptive sensory diversity tuning in Escherichia coli chemotaxis.
Article in Cell systems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Growth-dependent sensory bet-hedging enhances collective navigation.bioRxiv : the preprint server for biology · 2026Article
- Article
- Single-array measurements reveal non-uniform, mosaic-like chemosensory arrays in bacteria.Nature communications · 2025Article
- When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- ChemotaxingbioRxiv : the preprint server for biology · 2025Article
- ChemotaxingArXiv · 2025Article
- Article
- Article
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Abstract
In uncertain environments, phenotypic diversity can be advantageous for survival. However, as the environmental uncertainty decreases, the relative advantage of having diverse phenotypes decreases. Here, we show how populations of E. coli integrate multiple chemical signals to adjust sensory diversity in response to changes in the prevalence of each ligand in the environment. Measuring kinase activity in single cells, we quantified the sensitivity distribution to various chemoattractants in different mixtures of background stimuli. We found that when ligands bind uncompetitively, the population tunes sensory diversity to each signal independently, decreasing diversity when the signal's ambient concentration increases. However, among competitive ligands, the population can only decrease sensory diversity one ligand at a time. Mathematical modeling suggests that sensory diversity tuning benefits E. coli populations by modulating how many cells are committed to tracking each signal proportionally as their prevalence changes.
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