Evidence map›Paper›PMID 38981455›Full record

ArticleFetal diagnosis and therapy2024

North American Fetal Therapy Network: Maternal Outcomes in Fetal Aqueductal Stenosis.

Stephen P Emery, Samia Lopa, Erika Peterson, Jena L Miller, Marjorie C Treadwell, Juliana Gebb, Henry Galan, Eric P Bergh, Amanda Criebaum, Amelia McLennan and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fetal diagnosis and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Stephen P EmeryDepartment of Obstetrics, Gynecology, and Reproductive Sciences, UPMC Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Samia LopaDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Erika PetersonDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA.
Jena L MillerDepartment of Gynecology and Obstetrics, The Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland, USA.
Marjorie C TreadwellDepartment of Obstetrics and Gynecology, University of Michigan Hospital, University of Michigan, Ann Arbor, Michigan, USA.
Juliana GebbDivision of Pediatric General, Fetal and Thoracic Surgery, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Henry GalanDepartment of Obstetrics and Gynecology, Children's Hospital Colorado, University of Colorado School of Medicine, Denver, Colorado, USA.
Eric P BerghDepartment of Obstetrics and Gynecology, Children's Memorial Hermann Hospital, University of Texas at Houston, Houston, Texas, USA.
Amanda CriebaumDepartment of Obstetrics and Gynecology, St. Louis Fetal Care Institute, St. Louis, Missouri, USA.
Amelia McLennanDepartment of Obstetrics and Gynecology, UC Davis Medical Center, University of California Davis, Sacramento, California, USA.
Joseph B LillegardDepartment of Surgery, Children's Minnesota, Minneapolis, Minnesota, USA.
Yair J BlumenfeldDepartment of Obstetrics and Gynecology, Stanford Medicine Children's Health, Stanford University, Palo Alto, California, USA.
Ozhan M TuranDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, Maryland, USA.
David C StreitmanDepartment of Obstetrics and Gynecology, Riley Children's Hospital, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Renal Anhydramnios Fetal Therapy (RAFT) TrialR01HD100540 · NICHD · JOHNS HOPKINS UNIVERSITY · PI ATKINSON, MEREDITH ANN, MILLER, JENA L · 2020 to 2024
$3.2M
NORTH AMERICAN FETAL THERAPY NETWORK BIANNUAL SCIENTIFIC MEETINGSR13HD059293 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JOHNSON, ANTHONY · 2009 to 2018
$60k
NICHD NIH HHS R01 HD100540NICHD NIH HHS R13 HD059293
6 · The paper itself

Abstract

introductionFetal aqueductal stenosis (AS) affects approximately 1:10,000 pregnancies. Obstruction of cerebral spinal fluid circulation occurs at the aqueduct of Sylvius, leading to progressive hydrocephalus and macrocephaly, which often necessitates cesarean section (CS). The purpose of this study was to describe maternal outcomes associated with fetal AS.

methodsThis study is conducted through the North American Fetal Therapy Network (NAFTNet). Subjects with a prenatal diagnosis of severe fetal central nervous system ventriculomegaly were recruited and followed longitudinally. Maternal events around the delivery of fetuses with AS were recorded and analyzed.

resultsThirty-seven subjects with fetal AS confirmed by neonatal neuroimaging were analyzed. The average gestational age at delivery was 36.7 weeks. Overall, 86% were delivered by CS, and 62% of these were elective. Ninety-one percent of CSs were performed through a Pfannenstiel abdominal incision. A classical uterine incision was required in 13% of cesarean deliveries. The peripartum complication rate was 27%.

conclusionWomen carrying a fetus with AS were at risk for preterm birth, cesarean delivery, a classical uterine incision, and peripartum complications. These data highlight the maternal morbidity associated with fetal AS and the potential benefit of in utero therapy not only for neonatal outcomes but also for maternal outcomes.

Indexed as

HydrocephalusAdultCerebral AqueductCesarean SectionFemaleFetal DiseasesFetal TherapiesHumansInfant, NewbornPregnancyPregnancy OutcomePremature BirthFetal aqueductal stenosisHydrocephalusMaternal complicationsVentriculomegaly

Identifiers

PMID38981455
PMCPMC11631658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.