Evidence map›Paper›PMID 38981096›Full record

ArticleACS synthetic biology2024

Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening.

Robert C Hurt, Zhiyang Jin, Mohamed Soufi, Katie K Wong, Daniel P Sawyer, Hao K Shen, Przemysław Dutka, Ramya Deshpande, Ruby Zhang, David R Mittelstein and 1 more

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Super-Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  3. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  4. Review
  5. Article
  6. Acoustic percolation switches enable targeted drug delivery controlled by diagnostic ultrasound.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mohamed Soufi
Katie K Wong
Daniel P Sawyer
Przemysław Dutka
Ramya Deshpande
Ruby Zhang
David R Mittelstein
Mikhail G ShapiroORCID 0000-0002-0291-4215

Funding

Biogenic Gas Nanostructures As Molecular Imaging Reporters For UltrasoundR01EB018975 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Mikhail Shapiro · 2014 to 2026
$5.9M
NIBIB NIH HHS R01 EB018975
6 · The paper itself

Abstract

A major challenge in the fields of biological imaging and synthetic biology is noninvasively visualizing the functions of natural and engineered cells inside opaque samples such as living animals. One promising technology that addresses this limitation is ultrasound (US), with its penetration depth of several cm and spatial resolution on the order of 100 μm. Within the past decade, reporter genes for US have been introduced and engineered to link cellular functions to US signals

Indexed as

Directed Molecular EvolutionGenes, ReporterAcousticsEscherichia coliHigh-Throughput Screening AssaysNanostructuresacoustic reporter genesdirected evolutiongas vesicleshigh-throughput screeningultrasound

Identifiers

PMID38981096
PMCPMC11264329

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.