ArticlePloS one2024
The relationship between complete blood cell count-derived inflammatory biomarkers and benign prostatic hyperplasia in middle-aged and elderly individuals in the United States: Evidence from NHANES 2001-2008.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Age trumps metabolism: No independent association between lipids, statins, and prostate enlargement in a metabolically controlled cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- Development and validation of a discrimination model for benign prostatic hyperplasia: key influencing factors, interaction effects, and the protective role of g-tocopherol.Translational andrology and urology · 2026Article
- Enhanced predictive value of post-treatment lymphocyte-based immunoinflammatory biomarkers for cancer therapy-related cardiac dysfunction in anthracycline-treated breast cancer patients.Cardio-oncology (London, England) · 2026Article
- Development and explainability of a machine learning prediction model for histological prostatic inflammation in surgically treated patients with benign prostatic hyperplasia: a single-center internal validation study.Frontiers in medicine · 2026Article
- The relationship between social risk profile of middle-aged and older adults in the united States and circadian syndrome and all-cause mortality: evidence from NHANES 2007-2018.BMC public health · 2025Article
- Predictors and predictive performance of immune-inflammation indices for symptom severity in benign prostatic hyperplasia.Scientific reports · 2025Article
- Integrated machine learning and population attributable fraction analysis of systemic inflammatory indices for mortality risk prediction in diabetes and prediabetes.Annals of medicine · 2025Article
- Inflammatory index-based nomogram for risk stratification of erectile dysfunction: a cross-sectional study with dual-cohort validation and mendelian randomization analysis.Translational andrology and urology · 2025Article
- Association between metabolic syndrome and risk of benign prostatic hyperplasia: a prospective cohort study of 163 975 participants.Journal of global health · 2025Article
- Predicting overactive bladder from inflammatory markers: A machine learning approach using NHANES 2005-2020.Biomolecules & biomedicine · 2025Article
- Systemic Inflammatory Biomarkers in Alopecia Areata: The Role of SII, SIRI, and CRP/Albumin Ratio.Dermatology practical & conceptual · 2025Article
- The association between eight complete blood count-derived inflammatory markers and muscle health.Frontiers in nutrition · 2025Article
- The Relationship Between Immune-Inflammatory Indexes and the Severity of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Cross-Sectional Study at a Tertiary Hospital in China.Journal of inflammation research · 2025Article
- Machine learning based association between inflammation indicators (NLR, PLR, NPAR, SII, SIRI, and AISI) and all-cause mortality in arthritis patients with hypertension: NHANES 1999-2018.Frontiers in public health · 2025Article
- The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States.Scientific reports · 2024Article
- Letter to the editor on: "Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study".The journal of nutrition, health & aging · 2024Article
- Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005-2008.Frontiers in nutrition · 2024Article
- Analysis of changes in platelet parameters and inflammatory markers in intrahepatic cholestasis of pregnancy before disease development.American journal of translational research · 2024Article
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5 authors.
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Abstract
backgroundBenign prostatic hyperplasia (BPH) is a common health disorder of the male genitourinary system with a high prevalence, especially among middle-aged and older adults, which seriously affects men's quality of life. Inflammatory markers derived from complete blood cell count (CBC) have previously been considered a prognostic indicator for various diseases, but little is known about their relationship with BPH. This study evaluated the relationship between complete blood cell count (CBC)-derived inflammatory biomarkers and BPH.
methodsData for this cross-sectional study were gathered from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2008. Using multiple logistic regressions, the study examined the association between benign prostatic hyperplasia(BPH) and Inflammatory biomarkers derived from blood cell counts such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), Systemic Inflammatory Response Index (SIRI) and Systemic Immunoinflammatory Index (SII).
results3,919 participants were included, with a median age of 61.00 (52.00-71.00) years old. Among them, 609 participants had benign prostatic hyperplasia, with a prevalence of 15.54%. Upon accounting for confounding factors, the study revealed a positive correlation between the plurality of BPH PLR and SII. However, MLR, NLR, and SIRI did not significantly correlate with the prevalence of BPH (p>0.05). In contrast to the lowest quartile, higher quartiles of PLR (OR = 1.93[1.38-2.69]) and SII (OR = 1.71[1.22-2.40]) were linked to an elevated risk of BPH. Interaction tests showed that age, body mass index, hypertension, diabetes, smoking, and drinking had no significant effect on this positive correlation (p for interaction>0.05). In addition, we found a roughly linear association between SII, PLR, and BPH using smoothed curve fitting.
conclusionsAccording to our research, high levels of PLR and SII are positively linked with an increased risk of BPH in middle-aged and elderly individuals in the United States. The results compensate for previous studies that still need to be validated with larger prospective cohorts.
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