Evidence map›Paper›PMID 38980654›Full record

ArticleJournal of cardiovascular translational research2024

Circulating circ_0069094 is Correlated with the Present and Endothelial Injury of Acute Coronary Syndrome.

Zhen Gao, Peng Wu, Hezhong Zhu, Jieqiong Chen, Wei Liu, Jiangtao Huo, Chaoyong He, Yang Duan, Jiajuan Chen

Abstract read
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Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhen GaoDepartment of Cardiology, Taihe Hospital, Hubei University of Medicine, No. 32, Renmin South Road, Shiyan, 442000, China.
Peng WuDepartment of Cardiovascular Medicine, Ya'an People's Hospital, Ya'an, 625000, China.
Hezhong ZhuDepartment of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
Jieqiong ChenDepartment of Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
Wei LiuDepartment of General Practitioner, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
Jiangtao HuoDepartment of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
Chaoyong HeDepartment of Cardiology, Taihe Hospital, Hubei University of Medicine, No. 32, Renmin South Road, Shiyan, 442000, China.
Yang DuanDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical University, No.99 Huaihai West Road, Quanshan District, Xuzhou, 221000, China. v2dy1g@163.com.
Jiajuan ChenDepartment of Cardiology, Taihe Hospital, Hubei University of Medicine, No. 32, Renmin South Road, Shiyan, 442000, China. chenjiajuan0719@163.com.ORCID 0000-0002-8938-2468

Funding

Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica S23064the Affiliated Hospital of Xuzhou Medical University Grant No. 2022104929the key research and development plan (social development) of the Science and Technology Project of Xuzhou City, Jiangsu Province Grant No. KC23274
6 · The paper itself

Abstract

To investigate the impacts of circ_0069094 on acute coronary syndrome. Real-time polymerase chain reaction was used to detect the expression levels of circ_0069094, and its diagnostic performance was evaluated using ROC curve. Spearman's method was performed for correlation analysis. The levels of SOD, MDA, vWF in ACS rat models were assessed by commercial kits. The activities of H/R cell models were detected by CCK-8, Transwell, flow cytometry. The GO and KEGG were performed to analyze the function of targeted genes of miR-484. The concentration of circ_0069094 was decreased in patients with ACS, ACS rat models and H/R HUVEC models. The dysfunction of SOD, MDA, vWF, LVIDs, LVDD, and LVEF in the ACS models was regulated by the increase of circ_0069094. The viability, migration, apoptosis of the H/R models were regulated by circ_0069094. MiR-484 was a ceRNA of circ_0069094 and mediated the function of circ_0069094.

Indexed as

Acute Coronary SyndromeApoptosisDisease Models, AnimalMicroRNAsRNA, CircularAgedAnimalsBiomarkersCell MovementFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMaleMiddle AgedMyocytes, CardiacBiomarkersMicroRNAsRNA, CircularACScirc_0069094Endothelial injurymiR-484Oxidative

Identifiers

PMID38980654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.