Evidence map›Paper›PMID 38980571›Full record

Trial reportBreast cancer (Tokyo, Japan)2024

The effect of exercise and educational programs for breast cancer patients on the development of breast cancer-related lymphoedema: secondary endpoint from a randomized controlled trial in the Setouchi Breast Project-10.

Shogo Nakamoto, Takayuki Iwamoto, Naruto Taira, Yukiko Kajiwara, Kengo Kawada, Daisuke Takabatake, Yuichiro Miyoshi, Shinichiro Kubo, Yoko Suzuki, Mari Yamamoto and 12 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Breast cancer (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013-2023).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Shogo NakamotoDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Takayuki IwamotoDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan. tiwamoto@med.kawasaki-m.ac.jp.ORCID http://orcid.org/0000-0001-5835-5160
Naruto TairaDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Yukiko KajiwaraDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Kengo KawadaDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Daisuke TakabatakeDepartment of Breast and Thyroid Surgery, Kochi Health Science Center, Kochi, Japan.
Yuichiro MiyoshiDepartment of Breast Oncology, NHO Shikoku Cancer Center, Matsuyama, Japan.
Shinichiro KuboDepartment of Breast and Thyroid Surgery, Fukuyama City Hospital, Fukuyama, Japan.
Yoko SuzukiDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Mari YamamotoDepartment of Breast and Thyroid Surgery, Fukuyama City Hospital, Fukuyama, Japan.
Yutaka OgasawaraDepartment of Breast Endocrine Surgery, Kagawa Prefectural Center Hospital, Takamatsu, Japan.
Minami HatonoDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Seiji YoshitomiDepartment of Breast and Endocrine Surgery, Red Cross Okayama Hospital, Okayama, Japan.
Kyoko HaraDepartment of Breast and Endocrine Surgery, Red Cross Okayama Hospital, Okayama, Japan.
Asako SasaharaDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Shozo OhsumiDepartment of Breast Oncology, NHO Shikoku Cancer Center, Matsuyama, Japan.
Masahiko IkedaDepartment of Breast and Thyroid Surgery, Fukuyama City Hospital, Fukuyama, Japan.
Hiroyoshi DoiharaDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Yuri MizotaShizuoka Graduate University of Public Health, Nagaizumi-cho, Japan.
Seiichiro YamamotoShizuoka Graduate University of Public Health, Nagaizumi-cho, Japan.
Tadahiko ShienDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Shinichi ToyookaDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Funding

Japan Society for the Promotion of Science London 15K01714Japan Society for the Promotion of Science London 19K10622
6 · The paper itself

Abstract

backgroundAlthough the association between higher physical activity and preventive effect on breast-cancer-related lymphoedema (BCRL) has been reported, it is unclear what intervention is optimal. We aimed to investigate the effect of exercise and educational programs on BCRL development.

methodsThis study was a secondary endpoint analysis from a prospective randomized controlled trial. We enrolled patients with stage 0-III breast cancer from March 2016 to March 2020 and randomly assigned them to the control (n = 111), education (n = 115), or exercise (n = 104) group. As secondary endpoint, we assessed the incidence of and preventive effect on BCRL at 12 months post-intervention.

resultsThere were no significant differences in the incidence of BCRL at 12 months post-intervention between the exercise and control groups (9.8% and 10.8%, P = 0.83) and the education and control groups (11.6% and 10.8%, P = 1.00). There were no significant differences in time to BCRL onset from the day of surgery between the exercise and control groups (event rate at 12 months: 20.7% and 17.2%, log-rank, P = 0.54) and the education and control groups (18.8% and 17.2%, log-rank, P = 0.57). The multivariable analyses indicated that axillary dissection and obesity significantly increased the risk of BCRL [hazard ratio (HR): 2.36, 95% confidence interval (CI) 1.52-3.67 and HR: 1.68, 95% CI 1.07-2.63, respectively].

conclusionsThe intervention did not decrease the risk of BCRL, and axillary dissection and obesity were the risk factors of BCRL. TRIAL REGISTRATION NUMBER: UMIN000020595 at UMIN Clinical Trial Registry.

Indexed as

Breast Cancer LymphedemaBreast NeoplasmsAdultAgedExerciseExercise TherapyFemaleHumansIncidenceLymphedemaMastectomyMiddle AgedPatient Education as TopicProspective StudiesBreast cancerBreast cancer-related lymphoedemaEducational programExercise programPreventive effect

Identifiers

PMID38980571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.