Evidence map›Paper›PMID 38980364›Full record

ReviewSkeletal radiology2024

Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.

Xiaojuan Li, Jeehun Kim, Mingrui Yang, Ahmet H Ok, Štefan Zbýň, Thomas M Link, Sharmilar Majumdar, C Benjamin Ma, Kurt P Spindler, Carl S Winalski

Abstract readReview
In one paragraph

Review in Skeletal radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Correlation between functional impairment and quantitative MRI assessment of ankle cartilage in chronic ankle instability.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  7. Highly Accelerated TNMR in biomedicine · 2026
    Article
  8. [EJNMMI research · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaojuan LiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA. lix6@ccf.org.
Jeehun KimProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.
Mingrui YangProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.
Ahmet H OkProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.
Štefan ZbýňProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California San Francisco (UCSF), San Francisco, CA, USA.
Sharmilar MajumdarDepartment of Radiology and Biomedical Imaging, University of California San Francisco (UCSF), San Francisco, CA, USA.
C Benjamin MaDepartment of Orthopaedic Surgery, UCSF, San Francisco, CA, USA.
Kurt P SpindlerProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.
Carl S WinalskiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.

Funding

BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL ReconstructionR01AR074131 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SPINDLER, KURT PAUL · 2018 to 2024
$6.0M
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRIR01AR075422 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOJUAN, SPINDLER, KURT PAUL · 2019 to 2023
$4.6M
Multi-Vendor Multi-Site Novel Accelerated MRI RelaxometryR01AR077452 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOJUAN · 2020 to 2025
$3.6M
Understanding the mechanisms by which weight change affects progression of knee osteoarthritis in obese and overweight individuals: An analysis of the Osteoarthritis Initiative DatasetR01AR078917 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GABRIELLE JOSEPH, THOMAS M LINK · 2021 to 2026
$3.4M
Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyR56AR053684 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SPINDLER, KURT PAUL · 2022 to 2022
$704k
Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep LearningK25AR078928 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI Mingrui Yang · 2022 to 2026
$678k
NIAMS NIH HHS K25 AR078928NIAMS NIH HHS R01 AR078917NIH/NIAMS K25AR078928NIH/NIAMS R01AR074131NIH/NIAMS R01AR075422NIH/NIAMS R01AR077452NIH/NIAMS R01AR078917NIH/NIAMS R56AR053684
6 · The paper itself

Abstract

Articular cartilage damage and degeneration are among hallmark manifestations of joint injuries and arthritis, classically osteoarthritis. Cartilage compositional MRI (Cart-C MRI), a quantitative technique, which aims to detect early-stage cartilage matrix changes that precede macroscopic alterations, began development in the 1990s. However, despite the significant advancements over the past three decades, Cart-C MRI remains predominantly a research tool, hindered by various technical and clinical hurdles. This paper will review the technical evolution of Cart-C MRI, delve into its clinical applications, and conclude by identifying the existing gaps and challenges that need to be addressed to enable even broader clinical application of Cart-C MRI.

Indexed as

Cartilage, ArticularMagnetic Resonance ImagingHumansOsteoarthritisBiomarkersCartilageComposition MRIOsteoarthritisQuantitative imaging

Identifiers

PMID38980364
PMCPMC11303573

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.