Evidence map›Paper›PMID 38980156›Full record

ArticleACS applied materials & interfaces2024

Bottlebrush Polymers for Articular Joint Lubrication: Influence of Anchoring Group Chemistry on Lubrication Properties.

Karolina Turczyńska, Mahdi Rahimi, Gholamreza Charmi, Duy Anh Pham, Hironobu Murata, Marcin Kozanecki, Paulina Filipczak, Jacek Ulański, Tadeusz Diem, Krzysztof Matyjaszewski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karolina TurczyńskaDepartment of Molecular Physics, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Mahdi RahimiOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, H4J 1C5 Montréal, QC, Canada.
Gholamreza CharmiInstitute of Polymer and Dye Technology, Faculty of Chemistry, Lodz University of Technology, Stefanowskiego 16, 90-537 Lodz, Poland.
Duy Anh PhamCanada Research Chair in Bio-inspired Materials and Interfaces, Faculty of Pharmacy, Université de Montréal, C.P. 6128, succursale Centre Ville, Montréal Qc H3T1J4, QC, Canada.
Hironobu MurataDepartment of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, 15213 Pittsburgh, Pennsylvania, United States.
Marcin KozaneckiDepartment of Molecular Physics, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.ORCID 0000-0001-7400-6315
Paulina FilipczakDepartment of Molecular Physics, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Jacek UlańskiDepartment of Molecular Physics, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Tadeusz DiemCollegium Civitas, Plac Defilad 1, 00-901 Warsaw, Poland.
Krzysztof MatyjaszewskiDepartment of Molecular Physics, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.ORCID 0000-0003-1960-3402
Xavier BanquyCanada Research Chair in Bio-inspired Materials and Interfaces, Faculty of Pharmacy, Université de Montréal, C.P. 6128, succursale Centre Ville, Montréal Qc H3T1J4, QC, Canada.ORCID 0000-0002-3342-3179
Joanna PietrasikInstitute of Polymer and Dye Technology, Faculty of Chemistry, Lodz University of Technology, Stefanowskiego 16, 90-537 Lodz, Poland.ORCID 0000-0001-7438-9627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of carboxylic, aldehyde, or epoxide groups incorporated into bottlebrush macromolecules as anchoring blocks (or cartilage-binding blocks) is investigated by measuring their lubricating properties and cartilage-binding effectiveness. Mica modified with amine groups is used to mimic the cartilage surface, while bottlebrush polymers functionalized with carboxylic, aldehyde, or epoxide groups played the role of the lubricant interacting with the cartilage surface. We demonstrate that bottlebrushes with anchoring blocks effectively reduce the friction coefficient on modified surfaces by 75-95% compared to unmodified mica. The most efficient polymer appears to be the one with epoxide groups, which can react spontaneously with amines at room temperature. In this case, the value of the friction coefficient is the lowest and equals 0.009 ± 0.001, representing a 95% reduction compared to measurements on nonmodified mica. These results show that the presence of the functional groups within the anchoring blocks has a significant influence on interactions between the bottlebrush polymer and cartilage surface. All synthesized bottlebrush polymers are also used in the preliminary lubrication tests carried out on animal cartilage surfaces. The developed materials are very promising for future

Indexed as

Cartilage, ArticularLubricationPolymersAluminum SilicatesAnimalsFrictionLubricantsSurface PropertiesAluminum SilicatesLubricantsmicaPolymersarticular cartilagebiolubricationbottlebrushesfriction coefficientosteoarthritis

Identifiers

PMID38980156
PMCPMC11284745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.