ArticleeLife2024
Selective recruitment of the cerebellum evidenced by task-dependent gating of inputs.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.Neuroscience and biobehavioral reviews · 2025Pooled it
- The cerebellum specializes for language even in the absence of contralateral neocortical inputs.bioRxiv : the preprint server for biology · 2026Article
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- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- The Human Cerebellum Encodes Temporally Sensitive Reinforcement Learning Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.IBRO neuroscience reports · 2026Review
- Cerebellar perturbation impairs human working memory and degrades spatial tuning throughout cortex.bioRxiv : the preprint server for biology · 2026Article
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- Multidimensional Motor Phenotype Characterization in Children with Joubert Syndrome: A Cross-Sectional Cohort Study.Journal of clinical medicine · 2026Article
- Article
- Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation.BMC medicine · 2026Article
- How does the cerebellum contribute to cognitive functions?PLoS biology · 2026Review
- The cerebellar components of the human language network.bioRxiv : the preprint server for biology · 2025Article
- The human cerebellum encodes temporally sensitive reinforcement learning signals.bioRxiv : the preprint server for biology · 2025Article
- First Application of a Novel Brain Template: Motor Training Improves Cortico-cerebellar Connectivity in Cerebellar Ataxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Alzheimer's disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity.Neurobiology of aging · 2025Article
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.bioRxiv : the preprint server for biology · 2025Article
- Complementary benefits of multivariate and hierarchical models for identifying individual differences in cognitive control.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A hierarchical Bayesian brain parcellation framework for fusion of functional imaging datasets.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) studies have documented cerebellar activity across a wide array of tasks. However, the functional contribution of the cerebellum within these task domains remains unclear because cerebellar activity is often studied in isolation. This is problematic, as cerebellar fMRI activity may simply reflect the transmission of neocortical activity through fixed connections. Here, we present a new approach that addresses this problem. Rather than focus on task-dependent activity changes in the cerebellum alone, we ask if neocortical inputs to the cerebellum are gated in a task-dependent manner. We hypothesize that input is upregulated when the cerebellum functionally contributes to a task. We first validated this approach using a finger movement task, where the integrity of the cerebellum has been shown to be essential for the coordination of rapid alternating movements but not for force generation. While both neocortical and cerebellar activity increased with increasing speed and force, the speed-related changes in the cerebellum were larger than predicted by an optimized cortico-cerebellar connectivity model. We then applied the same approach in a cognitive domain, assessing how the cerebellum supports working memory. Enhanced gating was associated with the encoding of items in working memory, but not with the manipulation or retrieval of the items. Focusing on task-dependent gating of neocortical inputs to the cerebellum offers a promising approach for using fMRI to understand the specific contributions of the cerebellum to cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.