Evidence map›Paper›PMID 38980038›Full record

ArticlemBio2024

Immunological correlates of protection mediated by a whole organism,

Charles A Specht, Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Christina Gomez, Zhongming Mou, Diana Carlson, Chrono K Lee, Camaron R Hole, Woei C Lam and 3 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Fungal vaccines: so needed, so feasible, and yet so far off.The Journal of clinical investigation · 2025
    Article
  6. Peripheral blood CD4The Journal of infection · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. State of the Field: Cytotoxic Immune Cell Responses inJournal of fungi (Basel, Switzerland) · 2024
    Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Charles A SpechtDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-5749-3112
Ruiying WangDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-3638-4582
Lorena V N OliveiraDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-1762-0076
Maureen M HesterDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Christina GomezDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Zhongming MouDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Diana CarlsonDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0009-0009-5268-0646
Chrono K LeeDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Camaron R HoleDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-9363-3020
Woei C LamDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Rajendra UpadhyaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-7613-2518
Jennifer K LodgeDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Stuart M LevitzDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-3799-3064

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
Large Scale T Cell Epitope Discovery75N93019C00064 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAGE, KASIA · 2019 to 2024
$6.3M
A subunit Cryptococcus vaccineR01AI172154 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2022 to 2026
$3.1M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) RO1 AI172154NIAID NIH HHS 75N93019C00064NIAID NIH HHS R01 AI125045NIAID NIH HHS R01 AI172154NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

The global burden of infections due to the pathogenic fungus IMPORTANCE: The fungus

Indexed as

CD4-Positive T-LymphocytesChitosanCryptococcosisCryptococcus neoformansFungal VaccinesAnimalsCD8-Positive T-LymphocytesFemaleInterferon-gammaMiceMice, Inbred C57BLChitosanFungal VaccinesInterferon-gammaAIDSCryptococcus neoformanslive vector vaccinesmycologyT cells

Identifiers

PMID38980038
PMCPMC11323574

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.