Evidence map›Paper›PMID 38980037›Full record

ArticlemBio2024

Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the

María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Josie Parker, Ziyan Xu, Steven Kelly, Joseph Heitman

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Osh2 mediatesAntimicrobial agents and chemotherapy · 2025
    Article
  4. Review
  5. Article
  6. A Comprehensive Analysis of the Lipidomic Signatures inJournal of fungi (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

María Isabel Navarro-Mendoza *Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-3560-6155
Carlos Pérez-Arques *Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-1384-3608
Josie ParkerMolecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.ORCID 0000-0002-3855-4194
Ziyan XuDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Steven KellyInstitute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom.ORCID 0000-0001-7991-5040
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-6369-5995

Funding

ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesisR01AI170543 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2022 to 2026
$3.6M
Astellas | Astellas Pharma Global Development (Astellas Pharma Global Development, Inc.) ISR005855/CRES-21B01HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI170543NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI170543
6 · The paper itself

Abstract

Mucormycoses are emerging fungal infections caused by a variety of heterogeneous species within the Mucorales order. Among the IMPORTANCE: The

Indexed as

Antifungal AgentsBiosynthetic PathwaysDrug Resistance, FungalErgosterolMucorFungal ProteinsGene DeletionHumansMicrobial Sensitivity TestsMucormycosisNitrilesOxidoreductasesPyridinesTriazolesAntifungal AgentsErgosterolFungal ProteinsisavuconazoleNitrilesOxidoreductasesposaconazolePyridinessterol delta-5 desaturaseTriazolesantifungal resistanceErg3Erg6ergosterolfungigenetic tranformationMucorales

Identifiers

PMID38980037
PMCPMC11323496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.