Evidence map›Paper›PMID 38979869›Full record

ArticleExperimental physiology2024

Tetrodotoxin-resistant mechanosensitivity and L-type calcium channel-mediated spontaneous calcium activity in enteric neurons.

Richard J Amedzrovi Agbesi, Amira El Merhie, Nick J Spencer, Tim Hibberd, Nicolas R Chevalier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Endothelin-3 and T-type CaNature communications · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Richard J Amedzrovi AgbesiLaboratoire Matière et Systèmes Complexes UMR 7057, Université Paris Cité/CNRS, Paris, France.
Amira El MerhieLaboratoire Matière et Systèmes Complexes UMR 7057, Université Paris Cité/CNRS, Paris, France.
Nick J SpencerCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Tim HibberdCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Nicolas R ChevalierLaboratoire Matière et Systèmes Complexes UMR 7057, Université Paris Cité/CNRS, Paris, France.ORCID https://orcid.org/0000-0002-9713-1511

Funding

Agence Nationale de la Recherche ANR-10-INBS-04Agence Nationale de la Recherche ANR-11-EQPX-0029Agence Nationale de la Recherche ANR-11-LABX-0071Agence Nationale de la Recherche ANR-18-IDEX-0001Agence Nationale de la Recherche GASTROMOVE-ANR-19-CE30-0016-01DHAC | National Health and Medical Research Council (NHMRC) 1156416IDEX Université de ParisImaging platform Bioemergences-IBiSA and Imagoseine
6 · The paper itself

Abstract

Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell derivatives. We found that spontaneous calcium activity is tetrodotoxin (TTX) resistant at stage E11.5, but not at E18.5. Motility at E18.5 was characterized by periodic, alternating high- and low-frequency contractions of the circular smooth muscle; this frequency modulation was inhibited by TTX. Calcium imaging at the neurogenic-motility stages E18.5-P3 showed that Ca

Indexed as

CalciumCalcium Channels, L-TypeEnteric Nervous SystemGastrointestinal MotilityNeuronsTetrodotoxinAnimalsBoron CompoundsCalcium Channel BlockersFemaleMiceMice, Inbred C57BLMuscle ContractionMuscle, SmoothNicardipine2-aminoethoxydiphenyl borateBoron CompoundsCalciumCalcium Channel BlockersCalcium Channels, L-TypeNicardipineTetrodotoxin2‐APBadult gutcalcium imagingCaV1.2embryonic gutenteric nervous systemfetal gutGCampL‐type calcium channelmechanosensationmousetetrodotoxin

Identifiers

PMID38979869
PMCPMC11363105

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.