Evidence map›Paper›PMID 38979592›Full record

ArticlePathologica2024

Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis.

Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Alessia Piermattei, Maria Elisabetta Onori, Angelo Minucci, Luigi Pedone Anchora, Francesco Fanfani and 1 more

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In one paragraph

Article in Pathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Antonio TravaglinoGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Angela SantoroGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Damiano ArciuoloGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Giulia ScaglioneGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Antonio RaffoneGynecology and Obstetrics Unit, Department of Public Health, University of Naples Federico II, Naples, Italy.
Alessia PiermatteiGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Maria Elisabetta OnoriMolecular and Genomic Diagnostics Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Angelo MinucciMolecular and Genomic Diagnostics Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Luigi Pedone AnchoraGynecologic Oncology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Francesco FanfaniPathology Institute, Università Cattolica del Sacro Cuore, Rome, Italy.
Gian Franco ZannoniGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A corded and hyalinized pattern has been described in endometrial endometrioid carcinoma. Herein, we describe a clinicopathological and molecular analysis of the first reported case of endometrial serous carcinoma with a corded and hyalinized pattern. A 64-year-old woman underwent hysterectomy and bilateral salpingo-oophorectomy due to a 5.5 cm endometrial lesion. Histologically, the tumor was composed of a minor (20%) serous carcinoma component and a predominant corded component embedded in a hyaline-to-myxoid matrix. This component showed diffuse and strong p53 and p16 expression, heterogeneous positivity for epithelial markers and WT1, focal positivity for estrogen and progesterone receptors, retained MMR, SMARCA4/BRG1, and SMARCB1/INI1 expression, and negativity for smooth muscle, germ cell, sex cord, neuroendocrine, endothelial, and melanocytic markers and GATA3. Next-generation sequencing showed a mutation of uncertain significance in APC and no mutations in MLH1, MSH2, MSH6, PMS2, MUTYH, POLE, POLD1, EPCAM, or CTNNB1. The patient had a recurrence on the vaginal stump after 15 months. In conclusion, endometrial serous carcinoma can show a corded and hyalinized pattern, which may represent a diagnostic challenge.

Indexed as

Biomarkers, TumorEndometrial NeoplasmsCystadenocarcinoma, SerousFemaleHigh-Throughput Nucleotide SequencingHumansHysterectomyImmunohistochemistryMiddle AgedMutationSalpingo-oophorectomyBiomarkers, Tumorcorded and hyalinizedendometrial carcinomaimmunohistochemicalmolecularserous carcinoma

Identifiers

PMID38979592
PMCPMC11447659

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