Evidence map›Paper›PMID 38979426›Full record

ArticleFrontiers in immunology2024

Gut

Hongfeng Li, Junhui Dai, Changying Zhao, Tianqi Hu, Guoping Zhao, Qinghua Wang, Lei Zhang

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trending ileal microbiome dysbiosis over time as an early assessment of intestinal transplant rejection risk.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hongfeng Li *Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Junhui Dai *Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Changying Zhao *Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Tianqi HuMicrobiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Guoping ZhaoMicrobiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Qinghua WangSchool of Biological Science and Technology, University of Jinan, Jinan, China.
Lei ZhangMicrobiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A burgeoning body of evidence has substantiated the association between alterations in the composition of the gut microbiota and rheumatoid arthritis (RA). Nevertheless, our understanding of the intricate mechanisms underpinning this association is limited. Methods: To investigate whether the gut microbiota influences the pathogenesis of RA through metabolism or immunity, we performed rigorous synthesis analyses using aggregated statistics from published genome-wide association studies (GWAS) using two-sample Mendelian randomization (MR) and mediated MR techniques, including two-step MR and multivariate MR analyses. Subsequently, we conducted Results: Our univariable MR results confirmed 15 microbial traits, 7 metabolites and 2 cytokines that may be causally associated with RA ( Conclusion: The results of this study suggest that

Indexed as

Arthritis, RheumatoidCell Adhesion MoleculesGastrointestinal MicrobiomeEubacterialesGenome-Wide Association StudyHumansMendelian Randomization AnalysisTumor Necrosis Factor-alphaCell Adhesion MoleculesTNFAIP6 protein, humanTumor Necrosis Factor-alphagut microbiotamendelian randomizationpathway discoveryrheumatoid arthritistumor necrosis factor-inducible gene 6 protein

Identifiers

PMID38979426
PMCPMC11229780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.